Disease activity and damage in juvenile idiopathic arthritis: Methotrexate era versus biologic era
Giancane G., Muratore V., Marzetti V., Quilis N., Benavente B. S., Bagnasco F., Alongi A., Civino A., Quartulli L., Consolaro A., Ravelli A.
Arthritis Research and Therapy
Vol.21, Issue1, Num.168
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1186/s13075-019-1950-7
Аннотация:
Objective: To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras. Methods: Patients were included in MTX or biologic era cohort depending on whether their disease presentation occurred before or after January 2000. All patients had disease duration ≥ 5 years and underwent a prospective cross-sectional assessment, which included measurement of disease activity and damage. Inactive disease (ID) and low disease activity (LDA) states were defined according to Wallace, JADAS10, and cJADAS10 criteria. Articular and extraarticular damage was assessed with the Juvenile Arthritis Damage Index (JADI). Results: MTX and biologic era cohorts included 239 and 269 patients, respectively. Patients were divided in the "functional phenotypes" of oligoarthritis and polyarthritis. At cross-sectional visit, patients in the biologic era cohort with either oligoarthritis
Ключевые слова:
Biologic agents; Disease activity; Disease damage; Juvenile idiopathic arthritis; Long-term outcome; Methotrexate
C reactive protein; cyclosporine; glucocorticoid; methotrexate; antirheumatic agent; biological product; methotrexate; age distribution; Article; child; clinical feature; cohort analysis; controlled study; cross-sectional study; disease activity; disease classification; disease course; disease duration; erythrocyte sedimentation rate; female; human; Juvenile Arthritis Damage Index; juvenile rheumatoid arthritis; major clinical study; male; musculoskeletal disease assessment; onset age; prospective study; sex difference; treatment outcome; treatment response; visual analog scale; articular cartilage; drug effect; joint; juvenile rheumatoid arthritis; pathology; pathophysiology; preschool child; procedures; severity of illness index; Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Cartilage, Articular; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Joints; Male; Methotrexate; Outcome Assessment, Health Care; Prospective Studies; Severity of Illness Inde
Язык текста: Английский
ISSN: 1478-6362
Giancane G.
Muratore V.
Marzetti V.
Quilis N.
Benavente B. S.
Bagnasco F.
Alongi A.
Civino A.
Quartulli L.
Consolaro A.
Ravelli A. Anzhelo 1956-
Гианcане Г.
Мураторе В.
Марзетти В.
Qуилис Н.
Бенавенте Б. С.
Багнасcо Ф.
Алонги А.
Cивино А.
Qуартюлли Л.
Cонсоларо А.
Равелли А. Анжело 1956-
Disease activity and damage in juvenile idiopathic arthritis: Methotrexate era versus biologic era
Текст визуальный непосредственный
Arthritis Research and Therapy
BioMed Central Ltd.
Vol.21, Issue1 Num.168
2019
Статья
Biologic agents Disease activity Disease damage Juvenile idiopathic arthritis Long-term outcome Methotrexate
C reactive protein cyclosporine glucocorticoid methotrexate antirheumatic agent biological product methotrexate age distribution Article child clinical feature cohort analysis controlled study cross-sectional study disease activity disease classification disease course disease duration erythrocyte sedimentation rate female human Juvenile Arthritis Damage Index juvenile rheumatoid arthritis major clinical study male musculoskeletal disease assessment onset age prospective study sex difference treatment outcome treatment response visual analog scale articular cartilage drug effect joint juvenile rheumatoid arthritis pathology pathophysiology preschool child procedures severity of illness index Antirheumatic Agents Arthritis, Juvenile Biological Products Cartilage, Articular Child Child, Preschool Cross-Sectional Studies Female Humans Joints Male Methotrexate Outcome Assessment, Health Care Prospective Studies Severity of Illness Inde
Objective: To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras. Methods: Patients were included in MTX or biologic era cohort depending on whether their disease presentation occurred before or after January 2000. All patients had disease duration ≥ 5 years and underwent a prospective cross-sectional assessment, which included measurement of disease activity and damage. Inactive disease (ID) and low disease activity (LDA) states were defined according to Wallace, JADAS10, and cJADAS10 criteria. Articular and extraarticular damage was assessed with the Juvenile Arthritis Damage Index (JADI). Results: MTX and biologic era cohorts included 239 and 269 patients, respectively. Patients were divided in the "functional phenotypes" of oligoarthritis and polyarthritis. At cross-sectional visit, patients in the biologic era cohort with either oligoarthritis