Role of T Cell-To-Dendritic cell chemoattraction in T Cell priming initiation in the lymph node: An agent-based modeling study
Azarov I., Peskov K. V., Helmlinger G., Kosinsky Y.
Frontiers in Immunology
Vol.10, IssueJUN, Num.1289
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3389/fimmu.2019.01289
Аннотация:
The adaptive immune response is initiated in lymph nodes by contact between antigen-bearing dendritic cells (DCs) and antigen-specific T cells. A selected number of naïve T cells that recognize a specific antigen may proliferate into expanded clones, differentiate, and acquire an effector phenotype. Despite growing experimental knowledge, certain mechanistic aspects of T cell behavior in lymph nodes remain poorly understood. Computational modeling approaches may help in addressing such gaps. Here we introduce an agent-based model describing T cell movements and their interactions with DCs, leading to activation and expansion of cognate T cell clones, in a two-dimensional representation of the lymph node paracortex. The primary objective was to test the putative role of T cell chemotaxis toward DCs, and quantitatively assess the impact of chemotaxis with respect to T cell priming efficacy. Firstly, we evaluated whether chemotaxis of naïve T cells toward a nearest DC may accelerate the s
Ключевые слова:
Agent-based modeling; Chemotaxis; Dendritic cells; Lymph node; T cells
Article; calculation; cell density; cell expansion; cell interaction; cell motion; chemotaxis; dendritic cell; immune response; immunocompetent cell; lymphocyte proliferation; negative feedback; simulation; T lymphocyte; T lymphocyte activation
Язык текста: Английский
ISSN: 1664-3224
Azarov I.
Peskov K. V. Kirill Vitalyevich 1982-
Helmlinger G.
Kosinsky Y.
Азаров И.
Песков К. В. Кирилл Витальевич 1982-
Хелмлингер Г.
Косинскy Y.
Role of T Cell-To-Dendritic cell chemoattraction in T Cell priming initiation in the lymph node: An agent-based modeling study
Текст визуальный непосредственный
Frontiers in Immunology
Vol.10, IssueJUN Num.1289
2019
Статья
Agent-based modeling Chemotaxis Dendritic cells Lymph node T cells
Article calculation cell density cell expansion cell interaction cell motion chemotaxis dendritic cell immune response immunocompetent cell lymphocyte proliferation negative feedback simulation T lymphocyte T lymphocyte activation
The adaptive immune response is initiated in lymph nodes by contact between antigen-bearing dendritic cells (DCs) and antigen-specific T cells. A selected number of naïve T cells that recognize a specific antigen may proliferate into expanded clones, differentiate, and acquire an effector phenotype. Despite growing experimental knowledge, certain mechanistic aspects of T cell behavior in lymph nodes remain poorly understood. Computational modeling approaches may help in addressing such gaps. Here we introduce an agent-based model describing T cell movements and their interactions with DCs, leading to activation and expansion of cognate T cell clones, in a two-dimensional representation of the lymph node paracortex. The primary objective was to test the putative role of T cell chemotaxis toward DCs, and quantitatively assess the impact of chemotaxis with respect to T cell priming efficacy. Firstly, we evaluated whether chemotaxis of naïve T cells toward a nearest DC may accelerate the s