Spatial lymphocyte dynamics in lymph nodes predicts the cytotoxic T Cell frequency needed for HIV infection control
Grebennikov D. S., Bouchnita A., Volpert V., Bessonov N., Meyerhans A., Bocharov G. A.
Frontiers in Immunology
Vol.10, IssueJUN, Num.1213
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3389/fimmu.2019.01213
Аннотация:
The surveillance of host body tissues by immune cells is central for mediating their defense function. In vivo imaging technologies have been used to quantitatively characterize target cell scanning and migration of lymphocytes within lymph nodes (LNs). The translation of these quantitative insights into a predictive understanding of immune system functioning in response to various perturbations critically depends on computational tools linking the individual immune cell properties with the emergent behavior of the immune system. By choosing the Newtonian second law for the governing equations, we developed a broadly applicable mathematical model linking individual and coordinated T-cell behaviors. The spatial cell dynamics is described by a superposition of autonomous locomotion, intercellular interaction, and viscous damping processes. The model is calibrated using in vivo data on T-cell motility metrics in LNs such as the translational speeds, turning angle speeds, and meandering in
Ключевые слова:
Cell motility; Cytotoxic T cell scanning; Dissipative particle dynamics; HIV infection; Lymphoid tissue; Multicellular dynamics; Stochastic differential equation
Article; biophysics; cell interaction; cell migration; cell motion; cell subpopulation; contact inhibition; cytotoxic T lymphocyte; dendritic cell; Human immunodeficiency virus infection; immunocompetent cell; infection control; lymph node; lymphocyte; molecular dynamics; simulation
Язык текста: Английский
ISSN: 1664-3224
Grebennikov D. S. Dmitrij Sergeevich 1993-
Bouchnita A.
Volpert V.
Bessonov N.
Meyerhans A.
Bocharov G. A. Gennadij Alekseevich 1957-
Гребенников Д. С. Дмитрий Сергеевич 1993-
Боучнита А.
Волперт В.
Бессонов Н.
Меьерханс А.
Бочаров Г. А. Геннадий Алексеевич 1957-
Spatial lymphocyte dynamics in lymph nodes predicts the cytotoxic T Cell frequency needed for HIV infection control
Текст визуальный непосредственный
Frontiers in Immunology
Vol.10, IssueJUN Num.1213
2019
Статья
Cell motility Cytotoxic T cell scanning Dissipative particle dynamics HIV infection Lymphoid tissue Multicellular dynamics Stochastic differential equation
Article biophysics cell interaction cell migration cell motion cell subpopulation contact inhibition cytotoxic T lymphocyte dendritic cell Human immunodeficiency virus infection immunocompetent cell infection control lymph node lymphocyte molecular dynamics simulation
The surveillance of host body tissues by immune cells is central for mediating their defense function. In vivo imaging technologies have been used to quantitatively characterize target cell scanning and migration of lymphocytes within lymph nodes (LNs). The translation of these quantitative insights into a predictive understanding of immune system functioning in response to various perturbations critically depends on computational tools linking the individual immune cell properties with the emergent behavior of the immune system. By choosing the Newtonian second law for the governing equations, we developed a broadly applicable mathematical model linking individual and coordinated T-cell behaviors. The spatial cell dynamics is described by a superposition of autonomous locomotion, intercellular interaction, and viscous damping processes. The model is calibrated using in vivo data on T-cell motility metrics in LNs such as the translational speeds, turning angle speeds, and meandering in