Sarcomas of the mandible
Petrovic I., Ahmed Z. U., Hay A., Rosen E. B., Lu C., Hameed M., Sha D. P.
Journal of Surgical Oncology
Vol.120, Issue2, P. 109-116
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
Introduction: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma. Materials and methods: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed. Results: Twenty-two patients were treated over the study period, comprising of 15 males and seven females. External swelling, intraoral growth, or facial numbness were the presenting symptoms. Eighteen patients had osteosarcoma and four had the Ewing's sarcoma. Nine patients received neoadjuvant chemotherapy. All but one patient underwent surgery. Eleven had negative margins, with 90[%] recurrence-free survival at 3 years, compared to 10 with posi
Ключевые слова:
Ewing's sarcoma; mandible tumors; osteosarcoma; sarcoma
cisplatin; doxorubicin; etoposide; ifosfamide; methotrexate; adjuvant chemotherapy; adolescent; adult; aged; Article; cancer control; cancer radiotherapy; cancer survival; child; clinical article; disease specific survival; drug megadose; Ewing sarcoma; female; human; induction chemotherapy; male; mandible cancer; medical record review; neoadjuvant chemotherapy; osteosarcoma; overall survival; paresthesia; postoperative care; preschool child; priority journal; recurrence free survival; retrospective study; sarcoma; school child; swelling; symptom; tertiary health care; x-ray computed tomography; epidemiology; mandible tumor; middle aged; mortality; multimodality cancer therapy; prognosis; sarcoma; surgical margin; survival rate; tumor recurrence; young adult; Adolescent; Adult; Aged; Child; Combined Modality Therapy; Female; Humans; Male; Mandibular Neoplasms; Margins of Excision; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Sarcoma; Survival Rate; Young A
Язык текста: Английский
ISSN: 1096-9098
Petrovic I.
Ahmed Z. U.
Hay A.
Rosen E. B.
Lu C.
Hameed M.
Sha D. P. Dzhatin Premanand 1940-
Петровиc И.
Ахмед З. У.
Хай А.
Росен Е. Б.
Лу C.
Хамеед М.
Ша Д. П. Джатин Премананд 1940-
Sarcomas of the mandible
Текст визуальный непосредственный
Journal of Surgical Oncology
John Wiley & Sons
Vol.120, Issue2 P. 109-116
2019
Статья
Ewing's sarcoma mandible tumors osteosarcoma sarcoma
cisplatin doxorubicin etoposide ifosfamide methotrexate adjuvant chemotherapy adolescent adult aged Article cancer control cancer radiotherapy cancer survival child clinical article disease specific survival drug megadose Ewing sarcoma female human induction chemotherapy male mandible cancer medical record review neoadjuvant chemotherapy osteosarcoma overall survival paresthesia postoperative care preschool child priority journal recurrence free survival retrospective study sarcoma school child swelling symptom tertiary health care x-ray computed tomography epidemiology mandible tumor middle aged mortality multimodality cancer therapy prognosis sarcoma surgical margin survival rate tumor recurrence young adult Adolescent Adult Aged Child Combined Modality Therapy Female Humans Male Mandibular Neoplasms Margins of Excision Middle Aged Neoplasm Recurrence, Local Prognosis Retrospective Studies Sarcoma Survival Rate Young A
Introduction: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma. Materials and methods: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed. Results: Twenty-two patients were treated over the study period, comprising of 15 males and seven females. External swelling, intraoral growth, or facial numbness were the presenting symptoms. Eighteen patients had osteosarcoma and four had the Ewing's sarcoma. Nine patients received neoadjuvant chemotherapy. All but one patient underwent surgery. Eleven had negative margins, with 90[%] recurrence-free survival at 3 years, compared to 10 with posi