Association of Genes for Proinflammatory Cytokines and Depression
Lezhejko T. V., Andryushhenko A. V., Korovaitseva G. I., Kondratiev N. V., Gabaeva M. V., Krikova E. V., Golimbet V. E.
Neuroscience and Behavioral Physiology
Vol.49, Issue6, P. 749-753
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s11055-019-00796-y
Аннотация:
Objectives. To study the association between proinflammatory cytokines and depression. Materials and methods. The: IL-1β C-511T and TNF-α G-308A gene polymorphisms were studied in patients with diagnoses of “depression” (study group) and mentally healthy subjects of comparable sex and age (controls). Results and conclusions. An association between the IL-1β C-511T polymorphism and depression was found, where the variant with the risk of depression was the CC variant (p = 0.001, OR = 1.9, CI 1.3–2.7). An association was found between the TNF-α G-308A polymorphism and depression, where the risk variant was the GG genotype (p = 0.001, OR = 3.0, CI = 1.8–4.9). These data confirm the role of immune factors in the development of depression. The authors emphasize the role of the clinical polymorphism of depression, which makes it difficult to form homogeneous cohorts and to select phenotypes for biological studies. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
depression; inflammation; interleukins; proinflammatory cytokines
interleukin 1beta; tumor necrosis factor; adult; allele; Article; cohort analysis; controlled study; depression; female; gene frequency; genetic association; genetic polymorphism; genetic variability; genotype; human; IL 1beta gene; major clinical study; male; TNF alpha gene
Язык текста: Английский
ISSN: 1573-899X
Lezhejko T. V. Tat`yana Viktorovna 1975-
Andryushhenko A. V. Alisa Vladimirovna 1962-
Korovaitseva G. I.
Kondratiev N. V.
Gabaeva M. V.
Krikova E. V.
Golimbet V. E.
Лежейко Т. В. Татьяна Викторовна 1975-
Андрющенко А. В. Алиса Владимировна 1962-
Короваицева Г. И.
Кондратиев Н. В.
Габаева М. В.
Крикова Е. В.
Голимбет В. Е.
Association of Genes for Proinflammatory Cytokines and Depression
Текст визуальный непосредственный
Neuroscience and Behavioral Physiology
Springer New York Consultants Bureau
Vol.49, Issue6 P. 749-753
2019
Статья
depression inflammation interleukins proinflammatory cytokines
interleukin 1beta tumor necrosis factor adult allele Article cohort analysis controlled study depression female gene frequency genetic association genetic polymorphism genetic variability genotype human IL 1beta gene major clinical study male TNF alpha gene
Objectives. To study the association between proinflammatory cytokines and depression. Materials and methods. The: IL-1β C-511T and TNF-α G-308A gene polymorphisms were studied in patients with diagnoses of “depression” (study group) and mentally healthy subjects of comparable sex and age (controls). Results and conclusions. An association between the IL-1β C-511T polymorphism and depression was found, where the variant with the risk of depression was the CC variant (p = 0.001, OR = 1.9, CI 1.3–2.7). An association was found between the TNF-α G-308A polymorphism and depression, where the risk variant was the GG genotype (p = 0.001, OR = 3.0, CI = 1.8–4.9). These data confirm the role of immune factors in the development of depression. The authors emphasize the role of the clinical polymorphism of depression, which makes it difficult to form homogeneous cohorts and to select phenotypes for biological studies. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.