Molecular approaches for diagnosis, therapy and prevention of Cow´s milk allergy
Linhart B., Freidl R., Elisyutina O., Khaitov M., Karaulov A. V., Valenta R.
Nutrients
Vol.11, Issue7, Num.1492
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
Cow´s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow´s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to lifethreatening anaphylactic shock due to the stability of certain cow´s milk allergens. Here, we provide an overview about the allergen molecules in cow´s milk and the advantages of the molecular diagnosis of IgE sensitization to cow´s milk by serology. In addition, we review current strategies for prevention and treatment of cow´s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Ключевые слова:
Cow’s milk allergens; Cow’s milk allergy; Diagnosis of cow’s milk allergy; Molecular diagnosis; Prevention of cow’s milk allergy; Treatment of cow’s milk allergy
beta lactoglobulin; bovine serum albumin; casein; immunoglobulin A; immunoglobulin E; immunoglobulin G; interleukin 5; lactoferrin; prebiotic agent; probiotic agent; whey protein; allergenicity; amino acid sequence; anaphylaxis; calcium transport; CD8+ T lymphocyte; cell proliferation; constipation; cytokine production; food allergy; human; immunization; immunoreactivity; intestine flora; milk allergy; molecular cloning; molecular diagnosis; molecular therapy; nonhuman; patch test; pollen allergy; predictive value; pregnancy; prick test; protein expression; protein hydrolysis; protein intake; regulatory T lymphocyte; Review; sensitivity and specificity; sequence homology; serology
Язык текста: Английский
ISSN: 2072-6643
Linhart B.
Freidl R.
Elisyutina O.
Khaitov M.
Karaulov A. V. Aleksandr Viktorovich 1953-
Valenta R. Rudol`f 1963-
Линхарт Б.
Фреидл Р.
Елисютина О.
Хаитов М.
Караулов А. В. Александр Викторович 1953-
Валента Р. Рудольф 1963-
Molecular approaches for diagnosis, therapy and prevention of Cow´s milk allergy
Текст визуальный непосредственный
Nutrients
Vol.11, Issue7 Num.1492
2019
Обзор
Cow’s milk allergens Cow’s milk allergy Diagnosis of cow’s milk allergy Molecular diagnosis Prevention of cow’s milk allergy Treatment of cow’s milk allergy
beta lactoglobulin bovine serum albumin casein immunoglobulin A immunoglobulin E immunoglobulin G interleukin 5 lactoferrin prebiotic agent probiotic agent whey protein allergenicity amino acid sequence anaphylaxis calcium transport CD8+ T lymphocyte cell proliferation constipation cytokine production food allergy human immunization immunoreactivity intestine flora milk allergy molecular cloning molecular diagnosis molecular therapy nonhuman patch test pollen allergy predictive value pregnancy prick test protein expression protein hydrolysis protein intake regulatory T lymphocyte Review sensitivity and specificity sequence homology serology
Cow´s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow´s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to lifethreatening anaphylactic shock due to the stability of certain cow´s milk allergens. Here, we provide an overview about the allergen molecules in cow´s milk and the advantages of the molecular diagnosis of IgE sensitization to cow´s milk by serology. In addition, we review current strategies for prevention and treatment of cow´s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.