Аннотация:
The article presented data of the complex examination of 79 women aged of 24-43 years with uterine form of infertility, including the determination of immunohistochemical markers (ER, PR, Ki-67, CD34, CD56, CD68, CD138, VEGF) in endometrium. As a result of the study there was revealed the decline in the number of CD56-positive cells, decrease or no expression of CD138, the increase in expression of CD34, decreased VEGF expression. The deterioration of implantation processes in patients with uterine form of infertility, presumably is related to the low content of immune competent cells and inhibition of angiogenesis, as well as a weak proliferative activity of the endometrium, as evidenced by a decrease expression of Ki-67.
Arutyunyan N.A. Narina A.
Dzhibladze T.A. Tea A.
Зуев В.М. Первый МГМУ им. И.М. Сеченова МЗ РФ
Ishchenko A.I.
Брюнин Д.В. Первый МГМУ им. И.М. Сеченова МЗ РФ
Khokhlova I.D. Irina D.
Первый МГМУ им. И.М. Сеченова МЗ РФ
I.M. Sechenov First Moscow State Medical University
Zuev V.M. I.M. Sechenov First Moscow State Medical University
Bryunin D.V. I.M. Sechenov First Moscow State Medical University
Profile features immunohistochemical endometrium in patients uterine form of infertility
Текст визуальный электронный
Архив акушерства и гинекологии им. В.Ф. Снегирева
Eco-Vector
Т. 3, № 4 С. 193-197
2016
бесплодие
infertility
гиперплазия эндометрия
endometrial hyperplasia
хронический эндометрит
chronic endometritis
внутриматочные синехии
intrauterine synechia
иммуногистохимическое исследование
immunohistochemical studies
имплантация
implantation
Статья
The article presented data of the complex examination of 79 women aged of 24-43 years with uterine form of infertility, including the determination of immunohistochemical markers (ER, PR, Ki-67, CD34, CD56, CD68, CD138, VEGF) in endometrium. As a result of the study there was revealed the decline in the number of CD56-positive cells, decrease or no expression of CD138, the increase in expression of CD34, decreased VEGF expression. The deterioration of implantation processes in patients with uterine form of infertility, presumably is related to the low content of immune competent cells and inhibition of angiogenesis, as well as a weak proliferative activity of the endometrium, as evidenced by a decrease expression of Ki-67.