INVESTIGATION OF MICRORNA LEVELS IN BLOOD PLASMA IN PREGNANT WOMEN WITH GESTATIONAL ARTERIAL HYPERTENSION, PREECLAMPSIA, AND FETAL GROWTH RETARDATION SYNDROME
Murashko A.V., Simonova M.S., Goryunova A.G., Chebanov D.K., Abramov A.A., Chaplygin E.Y.
Архив акушерства и гинекологии им. В.Ф. Снегирева
Т. 5, № 2, С. 88-92
Опубликовано: 15 2018
Тип ресурса: Статья
DOI:10.18821/2313-8726-2018-5-2-88-92
Аннотация:
MicroRNAs are small non-coding RNAs (20-24 nucleotides) that regulate gene expression through post-transcriptional repression or degradation of the template RNA. The role of microRNA during pregnancy is currently poorly understood. Some studies have identified a microRNA profile associated with pregnancy since it was present in the placenta and maternal blood throughout pregnancy. In this study, we compared individual expression levels of 10 microRNAs in the maternal peripheral blood samples and further estimated their association with adverse pregnancy outcomes including preeclampsia, gestational arterial hypertension, and fetal growth retardation syndrome. MicroRNAs can be used as a non-invasive biomarker to identify an adverse obstetric outcome and with the potent therapeutic target for the prevention or treatment of pathology of pregnancy. Further research with a large sample size in different populations is needed to confirm our results.
Язык текста: Русский
ISSN: 2313-8726
Murashko A.V. Andrey V.
Simonova M.S.
Goryunova A.G.
Chebanov D.K.
Abramov A.A.
Chaplygin E.Y. E. Yu
I.M. Sechenov First Moscow State Medical University, V.F. Snegirev Clinic of Obstetrics and Gynecology
INVESTIGATION OF MICRORNA LEVELS IN BLOOD PLASMA IN PREGNANT WOMEN WITH GESTATIONAL ARTERIAL HYPERTENSION, PREECLAMPSIA, AND FETAL GROWTH RETARDATION SYNDROME
Текст визуальный электронный
Архив акушерства и гинекологии им. В.Ф. Снегирева
Eco-Vector
Т. 5, № 2 С. 88-92
2018
гестационная артериальная гипертензия
gestational arterial hypertension
преэклампсия
preeclampsia
синдром задержки роста плода
fetal growth retardation syndrome
беременность
pregnancy
микроРНК
microRNA
Статья
MicroRNAs are small non-coding RNAs (20-24 nucleotides) that regulate gene expression through post-transcriptional repression or degradation of the template RNA. The role of microRNA during pregnancy is currently poorly understood. Some studies have identified a microRNA profile associated with pregnancy since it was present in the placenta and maternal blood throughout pregnancy. In this study, we compared individual expression levels of 10 microRNAs in the maternal peripheral blood samples and further estimated their association with adverse pregnancy outcomes including preeclampsia, gestational arterial hypertension, and fetal growth retardation syndrome. MicroRNAs can be used as a non-invasive biomarker to identify an adverse obstetric outcome and with the potent therapeutic target for the prevention or treatment of pathology of pregnancy. Further research with a large sample size in different populations is needed to confirm our results.