Functionalized folic acid-conjugated amphiphilic alternating copolymer actively targets 3D multicellular tumour spheroids and delivers the...
Li X., Sambi M., Decarlo A., Burov S. V., Akasov R. A., Markvicheva E., Malardier-Jugroot C., Szewczuk M. R.
Nanomaterials
Vol.8, Issue8, Num.588
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosing the right cancer surface biomarker are critical for a targeted treatment to work. Currently, the available delivery systems use a two-dimensional monolayer of cancer cells to test the efficacy of the drug delivery system, but designing a “smart” drug delivery system to be specific for a tumour in vivo and to penetrate the inner core remains a major design challenge. These challenges can be overcome by using a study model that integrates the three-dimensional aspect of a tumour in a culture system. Here, we tested the efficacy of a functionalized folic acid-conjugated amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA) to
Ключевые слова:
5-fluorouracil; Amphiphilic alternating copolymer; Curcumin; Cyclo-RGDFK(TPP) peptide; Folate; Multicellular tumour spheroids; Paclitaxel; pH-responsive; Targeted drug delivery
Язык текста: Английский
ISSN: 2079-4991
Li X.
Sambi M.
Decarlo A.
Burov S. V.
Akasov R. A. Roman Aleksandrovich 1987-
Markvicheva E.
Malardier-Jugroot C.
Szewczuk M. R.
Ли Х.
Самби М.
Деcарло А.
Буров С. В.
Акасов Р. А. Роман Александрович 1987-
Марквичева Е.
Малардиер-Йугроот C.
Сзеwcзук М. Р.
Functionalized folic acid-conjugated amphiphilic alternating copolymer actively targets 3D multicellular tumour spheroids and delivers the hydrophobic drug to the inner core
Functionalized folic acid-conjugated amphiphilic alternating copolymer actively targets 3D multicellular tumour spheroids and delivers the...
Текст визуальный непосредственный
Nanomaterials
MDPI AG
Vol.8, Issue8 Num.588
2018
Статья
5-fluorouracil Amphiphilic alternating copolymer Curcumin Cyclo-RGDFK(TPP) peptide Folate Multicellular tumour spheroids Paclitaxel pH-responsive Targeted drug delivery
Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosing the right cancer surface biomarker are critical for a targeted treatment to work. Currently, the available delivery systems use a two-dimensional monolayer of cancer cells to test the efficacy of the drug delivery system, but designing a “smart” drug delivery system to be specific for a tumour in vivo and to penetrate the inner core remains a major design challenge. These challenges can be overcome by using a study model that integrates the three-dimensional aspect of a tumour in a culture system. Here, we tested the efficacy of a functionalized folic acid-conjugated amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA) to