Influence of interlejkines IL-1α, IL-1β and IL-1ra on development of male gamette in norm and hypospermatogenesis
Демяшкин Г. А., Коган Е. А., Ходжайан А. Б., Кулченко Н. Г., Демура Т. А., Гевандова М. Г., Шитов В. А.
Медицинский вестник Северного Кавказа
Т. 13, Вып. 2, С. 379-382
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.14300/mnnc.2018.13055
Аннотация:
Male fertility is based on complex intracellular signaling during spermatogenesis. Effect of Interleukin-1 (IL-1) and its homologues on spermatogenesis is actively studied. Nevertheless, its role in idiopathic infertility has not been sufficiently studied, especially in the phase of hypospermatogenesis. Aim: Evaluation of the expression of IL-1α, IL-1β and IL-1ra in human seminiferous tubules in idiopathic infertility. A retrospective study involved men (n=54) who complained of childlessness in a marriage for 2 years with the diagnosis of idiopathic infertility, established after a physical, medico-genetic, biochemical (hormone) and cytological (spermogram) analysis. The biopsy specimens obtained from the operation, as well as the autopsy material of men aged 22-35 years (n=10), were studied using the immunohistochemical method (antibodies: IL-1α, IL-1β and IL-1ra). At hypo-spermatogenesis, the maturation block, and Sertoli-cell syndrome, Leydig cells are marked to IL-1α, IL-1β labelin
Ключевые слова:
Hypospermatogenesis; Interleukins; Male infertility; Spermatogenesis
Язык текста: Русский
ISSN: 2073-8137
Демяшкин Г. А. Григорий Александрович 1976-
Коган Е. А. Евгения Алтаровна 1951-
Ходжайан А. Б.
Кулченко Н. Г.
Демура Т. А. Татьяна Александровна 1983-
Гевандова М. Г.
Шитов В. А.
Demyashkin G. A. Grigorij Aleksandrovich 1976-
Kogan E. A. Evgeniya Altarovna 1951-
Khodzhayan A. B.
Kulchenko N. G.
Demura T. A. Tat`yana Aleksandrovna 1983-
Gevandova M. G.
Shitov V. A.
Influence of interlejkines IL-1α, IL-1β and IL-1ra on development of male gamette in norm and hypospermatogenesis
Текст визуальный непосредственный
Медицинский вестник Северного Кавказа
Ставропольский государственный медицинский университет
Т. 13, Вып. 2 С. 379-382
2018
Статья
Hypospermatogenesis Interleukins Male infertility Spermatogenesis
Male fertility is based on complex intracellular signaling during spermatogenesis. Effect of Interleukin-1 (IL-1) and its homologues on spermatogenesis is actively studied. Nevertheless, its role in idiopathic infertility has not been sufficiently studied, especially in the phase of hypospermatogenesis. Aim: Evaluation of the expression of IL-1α, IL-1β and IL-1ra in human seminiferous tubules in idiopathic infertility. A retrospective study involved men (n=54) who complained of childlessness in a marriage for 2 years with the diagnosis of idiopathic infertility, established after a physical, medico-genetic, biochemical (hormone) and cytological (spermogram) analysis. The biopsy specimens obtained from the operation, as well as the autopsy material of men aged 22-35 years (n=10), were studied using the immunohistochemical method (antibodies: IL-1α, IL-1β and IL-1ra). At hypo-spermatogenesis, the maturation block, and Sertoli-cell syndrome, Leydig cells are marked to IL-1α, IL-1β labelin