Аннотация:
Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in th
Ключевые слова:
Cancer; Drug design; G-protein-coupled receptors; Hormonal systems; Kidney; Molecular targets of Urotensin II in cardiovascular; Nervous; Regulatory peptides; Sexual function; Stress; Urotensin II
G protein coupled receptor; urotensin; urotensin II; UTS2R protein, human; animal; antagonists and inhibitors; atherosclerosis; diabetes mellitus; heart failure; homeostasis; human; hypertension; kidney failure; metabolism; molecularly targeted therapy; Animals; Atherosclerosis; Diabetes Mellitus; Drug Therapy; Heart Failure; Homeostasis; Humans; Hypertension; Molecular Targeted Therapy; Receptors, G-Protein-Coupled; Renal Insufficiency; Urotensins
Svistunov A. A. Andrej Alekseevich 1965-
Tarasov V. V. Vadim Vladimirovich 1987-
Lebedeva S. A. Svetlana Anatolyevna 1974-
Sologova S. S. Susanna Sergeevna 1973-
Bagaturiya E. T. Ekaterina Tengizovna 1995-
Chubarev V. N. Vladimir Nikolaevich 1954-
Galenko-Yaroshevsky P. A.
Ávila-Rodriguez M. F.
Barreto G. E.
Aliev G. Gyumrakh 1958-
Свистунов А. А. Андрей Алексеевич 1965-
Тарасов В. В. Вадим Владимирович 1987-
Лебедева С. А. Светлана Анатольевна 1974-
Сологова С. С. Сусанна Сергеевна 1973-
Багатурия Е. Т. Екатерина Тенгизовна 1995-
Чубарев В. Н. Владимир Николаевич 1954-
Галенко-Ярошевскy П. А.
Áвила-Родригуез М. Ф.
Баррето Г. Е.
Алиев Г. Гюмрах 1958-
Urotensin II: Molecular mechanisms of biological activity
Текст визуальный непосредственный
Current Protein and Peptide Science
Bentham Science Publishers
Vol.19, Issue9 P. 924-934
2018
Обзор
Cancer Drug design G-protein-coupled receptors Hormonal systems Kidney Molecular targets of Urotensin II in cardiovascular Nervous Regulatory peptides Sexual function Stress Urotensin II
G protein coupled receptor urotensin urotensin II UTS2R protein, human animal antagonists and inhibitors atherosclerosis diabetes mellitus heart failure homeostasis human hypertension kidney failure metabolism molecularly targeted therapy Animals Atherosclerosis Diabetes Mellitus Drug Therapy Heart Failure Homeostasis Humans Hypertension Molecular Targeted Therapy Receptors, G-Protein-Coupled Renal Insufficiency Urotensins
Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in th