Аннотация:
Fibroblast growth factor (FGF) plays an important role in human embryogenesis, angiogenesis, cell proliferation, and differentiation. Carcinogenesis is accompanied by aberrant constitutive activation of FGF receptors (FGFRs) resulting from missense mutation in the FGFR1-4 genes, generation of chimeric oncogenes, FGFR1-4 gene amplification, alternative splicing shift toward formation of mesenchymal FGFR isoforms, and FGFR overexpression. Altogether, these alterations contribute to auto-and paracrine stimulation of cancer cells and neoangiogenesis. Certain missense mutations are found at a high rate in urinary bladder cancer and can be used for non-invasive cancer recurrence diagnostics by analyzing urine cell pellet DNA. Chimeric FGFR1/3 and amplified FGFR1/2 genes can predict cell response to the targeted therapy in various oncological diseases. In recent years, high-throughput sequencing has been used to analyze exomes of virtually all human tumors, which allowed to construct phylogen
Ключевые слова:
clonal evolution; fibroblast growth factor receptor; oncogene; somatic mutation; targeted therapy
fibroblast growth factor receptor; tumor marker; animal; antagonists and inhibitors; carcinogenesis; chemistry; drug effect; drug resistance; genetics; human; metabolism; mutation; signal transduction; Animals; Biomarkers, Tumor; Carcinogenesis; Drug Resistance, Neoplasm; Humans; Mutation; Receptors, Fibroblast Growth Factor; Signal Transduction
Mikhaylenko D. S. Dmitrij Sergeevich 1981-
Alekseev B. Y.
Zaletaev D. V. Dmitrij Vladimirovich 1956-
Goncharova R. I.
Nemtsova M. V. Marina Vyacheslavovna 1962-
Михайленко Д. С. Дмитрий Сергеевич 1981-
Алексеев Б. Y.
Залетаев Д. В. Дмитрий Владимирович 1956-
Гончарова Р. И.
Немцова М. В. Марина Вячеславовна 1962-
Structural Alterations in Human Fibroblast Growth Factor Receptors in Carcinogenesis
Текст визуальный непосредственный
Biochemistry (Moscow)
Pleiades Publishing, Ltd.
Vol.83, Issue8 P. 930-943
2018
Обзор
clonal evolution fibroblast growth factor receptor oncogene somatic mutation targeted therapy
fibroblast growth factor receptor tumor marker animal antagonists and inhibitors carcinogenesis chemistry drug effect drug resistance genetics human metabolism mutation signal transduction Animals Biomarkers, Tumor Carcinogenesis Drug Resistance, Neoplasm Humans Mutation Receptors, Fibroblast Growth Factor Signal Transduction
Fibroblast growth factor (FGF) plays an important role in human embryogenesis, angiogenesis, cell proliferation, and differentiation. Carcinogenesis is accompanied by aberrant constitutive activation of FGF receptors (FGFRs) resulting from missense mutation in the FGFR1-4 genes, generation of chimeric oncogenes, FGFR1-4 gene amplification, alternative splicing shift toward formation of mesenchymal FGFR isoforms, and FGFR overexpression. Altogether, these alterations contribute to auto-and paracrine stimulation of cancer cells and neoangiogenesis. Certain missense mutations are found at a high rate in urinary bladder cancer and can be used for non-invasive cancer recurrence diagnostics by analyzing urine cell pellet DNA. Chimeric FGFR1/3 and amplified FGFR1/2 genes can predict cell response to the targeted therapy in various oncological diseases. In recent years, high-throughput sequencing has been used to analyze exomes of virtually all human tumors, which allowed to construct phylogen