The prognostic role of circulating tumor cells (CTCs) in lung cancer
Kapeleris J., Kulasinghe A., Ibragimi V. M. M., Vela I., Kenny L., O'Byrne K., Punyadeera C.
Frontiers in Oncology
Vol.8, IssueAUG, Num.311
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.3389/fonc.2018.00311
Аннотация:
Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include "liquid biopsies" through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting. © 2018 Kapeleris, Kulasinghe, Warkiani, Vela, Kenny, O'Byrne and Punyadeera.
Ключевые слова:
Circulating tumor cells; Liquid biopsy; Lung cancer; NSCLC; SCLC
cancer prognosis; circulating tumor cell; epithelial mesenchymal transition; ex vivo study; histopathology; human; lung cancer; metastasis; nonhuman; Review
Язык текста: Английский
ISSN: 2234-943X
Kapeleris J.
Kulasinghe A.
Ibragimi V. M. M. Varkiani Madzhid Modzhtaba 1983-
Vela I.
Kenny L.
O'Byrne K.
Punyadeera C.
Капелерис Й.
Куласингхе А.
Ибрагими В. М. М. Варкиани Маджид Моджтаба 1983-
Вела И.
Кеннy Л.
О'Бyрне К.
Пунядеера C.
The prognostic role of circulating tumor cells (CTCs) in lung cancer
Текст визуальный непосредственный
Frontiers in Oncology
Vol.8, IssueAUG Num.311
2018
Обзор
Circulating tumor cells Liquid biopsy Lung cancer NSCLC SCLC
cancer prognosis circulating tumor cell epithelial mesenchymal transition ex vivo study histopathology human lung cancer metastasis nonhuman Review
Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include "liquid biopsies" through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting. © 2018 Kapeleris, Kulasinghe, Warkiani, Vela, Kenny, O'Byrne and Punyadeera.