Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage
Kaucka M., Petersen J., Tesarova M., Szarowska B., Kastriti M. E., Xie M., Kicheva A., Annusver K., Kasper M., Symmons O., Pan L., Spitz F., Kaiser J., Hovorakova M., Zikmund T., Sunadome K., Matise M. P., Wang H., Marklund U., Abdo H., Ernfors P., Maire P., Wurmser M., Chagin A. S., Fried K., Adameyko I.
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism res
Ключевые слова:
sonic hedgehog protein; Col2a1 protein, mouse; collagen type 2; cre recombinase; fusion protein; homeodomain protein; integrase; mutagenic agent; Nkx-2.2 homedomain protein; SHH protein, human; sonic hedgehog protein; tamoxifen; transcription factor; animal experiment; animal tissue; Article; bone development; brain; chondrogenesis; controlled study; embryo; embryo development; evolutionary adaptation; face development; facial bone; mammalian embryo; maxilla; micro-computed tomography; morphogenesis; mouse; mouse mutant; nasal capsule cartilage; nervous system; nonhuman; nose cartilage; nose septum; olfactory epithelium; phenotype; signal transduction; snout; three dimensional imaging; anatomy and histology; animal; brain; chondrocyte; cytology; drug effect; embryology; face; gene expression regulation; genetics; growth, development and aging; human; maxillofacial development; metabolism; nose cartilage; olfactory mucosa; transgenic mouse; Animals; Brain; Chondrocytes; Collagen Type II
Язык текста: Английский
ISSN: 2050-084X
Kaucka M.
Petersen J.
Tesarova M.
Szarowska B.
Kastriti M. E.
Xie M.
Kicheva A.
Annusver K.
Kasper M.
Symmons O.
Pan L.
Spitz F.
Kaiser J.
Hovorakova M.
Zikmund T.
Sunadome K.
Matise M. P.
Wang H.
Marklund U.
Abdo H.
Ernfors P.
Maire P.
Wurmser M.
Chagin A. S. Andrej Stanislavovich 1976-
Fried K.
Adameyko I.
Кауcка М.
Петерсен Й.
Тесарова М.
Сзароwска Б.
Кастрити М. Е.
Хие М.
Кичева А.
Аннусвер К.
Каспер М.
Сyммонс О.
Пан Л.
Спитз Ф.
Каисер Й.
Ховоракова М.
Зикмунд Т.
Сунадоме К.
Матисе М. П.
Wанг Х.
Марклунд У.
Абдо Х.
Ернфорс П.
Маире П.
Wурмсер М.
Чагин А. С. Андрей Станиславович 1976-
Фриед К.
Адамеyко И.
Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage
Текст визуальный непосредственный
eLife
eLife Sciences Publications, Ltd.
Vol.7 Num.e34465
2018
Статья
sonic hedgehog protein Col2a1 protein, mouse collagen type 2 cre recombinase fusion protein homeodomain protein integrase mutagenic agent Nkx-2.2 homedomain protein SHH protein, human sonic hedgehog protein tamoxifen transcription factor animal experiment animal tissue Article bone development brain chondrogenesis controlled study embryo embryo development evolutionary adaptation face development facial bone mammalian embryo maxilla micro-computed tomography morphogenesis mouse mouse mutant nasal capsule cartilage nervous system nonhuman nose cartilage nose septum olfactory epithelium phenotype signal transduction snout three dimensional imaging anatomy and histology animal brain chondrocyte cytology drug effect embryology face gene expression regulation genetics growth, development and aging human maxillofacial development metabolism nose cartilage olfactory mucosa transgenic mouse Animals Brain Chondrocytes Collagen Type II
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism res