Efficacy of zofenopril in combination with amlodipine in patients with acute myocardial infarction: a pooled individual patient data analysis of...
Borghi C., Omboni S., Reggiardo G., Bacchelli S., Degli E. D., Ambrosioni E.
Current Medical Research and Opinion
Vol.34, Issue10, P. 1869-1874
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1080/03007995.2018.1496076
Аннотация:
Objective: In the four SMILE (Survival of Myocardial Infarction Long-Term Evaluation) studies, early administration of zofenopril in acute myocardial infarction (AMI) showed beneficial effects as compared to placebo and other angiotensin converting enzyme inhibitors (ACEIs). This study investigated whether the concomitant administration of the dihydropyridine calcium channel-blocker amlodipine may improve zofenopril efficacy to prevent cardiovascular events in post-AMI patients. Methods: This was a post-hoc analysis of pooled individual patient data from the four large randomized SMILE studies. The primary endpoint was the 1-year combined occurrence of death or hospitalization for cardiovascular causes. Results: In total, 3488 patients were considered, 303 (8.7[%]) treated with concomitant amlodipine. Baseline systolic blood pressure and prevalence of metabolic syndrome were higher in amlodipine treated patients. The 1-year occurrence of major cardiovascular outcomes was significantly re
Ключевые слова:
Acute myocardial infarction; Amlodipine; Angiotensin-converting enzyme inhibitors; Cardiovascular risk; Drug therapy
amlodipine; lisinopril; placebo; ramipril; zofenopril; amlodipine; antihypertensive agent; captopril; zofenopril; acute heart infarction; adult; Article; cardiovascular disease; clinical outcome; combination drug therapy; controlled study; diastolic blood pressure; drug dose titration; drug efficacy; female; follow up; hospitalization; human; major clinical study; male; metabolic syndrome X; middle aged; post hoc analysis; prevalence; randomized controlled trial (topic); retrospective study; systolic blood pressure; treatment duration; aged; data analysis; double blind procedure; heart infarction; prognosis; randomized controlled trial; time to treatment; treatment outcome; Aged; Amlodipine; Antihypertensive Agents; Captopril; Data Analysis; Double-Blind Method; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Time-to-Treatment; Treatment Outcome
Язык текста: Английский
ISSN: 1473-4877
Borghi C.
Omboni S. Stefano 1963-
Reggiardo G.
Bacchelli S.
Degli E. D. Esposti D.
Ambrosioni E.
Боргхи C.
Омбони С. Стефано 1963-
Реггиардо Г.
Баcчелли С.
Дегли Е. Д. Еспости Д.
Амбросиони Е.
Efficacy of zofenopril in combination with amlodipine in patients with acute myocardial infarction: a pooled individual patient data analysis of four randomized, double-blind, controlled, prospective studies
Efficacy of zofenopril in combination with amlodipine in patients with acute myocardial infarction: a pooled individual patient data analysis of...
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Current Medical Research and Opinion
Librapharm Ltd.
Vol.34, Issue10 P. 1869-1874
2018
Статья
Acute myocardial infarction Amlodipine Angiotensin-converting enzyme inhibitors Cardiovascular risk Drug therapy
amlodipine lisinopril placebo ramipril zofenopril amlodipine antihypertensive agent captopril zofenopril acute heart infarction adult Article cardiovascular disease clinical outcome combination drug therapy controlled study diastolic blood pressure drug dose titration drug efficacy female follow up hospitalization human major clinical study male metabolic syndrome X middle aged post hoc analysis prevalence randomized controlled trial (topic) retrospective study systolic blood pressure treatment duration aged data analysis double blind procedure heart infarction prognosis randomized controlled trial time to treatment treatment outcome Aged Amlodipine Antihypertensive Agents Captopril Data Analysis Double-Blind Method Female Hospitalization Humans Male Middle Aged Myocardial Infarction Prognosis Time-to-Treatment Treatment Outcome
Objective: In the four SMILE (Survival of Myocardial Infarction Long-Term Evaluation) studies, early administration of zofenopril in acute myocardial infarction (AMI) showed beneficial effects as compared to placebo and other angiotensin converting enzyme inhibitors (ACEIs). This study investigated whether the concomitant administration of the dihydropyridine calcium channel-blocker amlodipine may improve zofenopril efficacy to prevent cardiovascular events in post-AMI patients. Methods: This was a post-hoc analysis of pooled individual patient data from the four large randomized SMILE studies. The primary endpoint was the 1-year combined occurrence of death or hospitalization for cardiovascular causes. Results: In total, 3488 patients were considered, 303 (8.7[%]) treated with concomitant amlodipine. Baseline systolic blood pressure and prevalence of metabolic syndrome were higher in amlodipine treated patients. The 1-year occurrence of major cardiovascular outcomes was significantly re