Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications
Khlestova G. V., Romanov A. Y., Nizyaeva N. V., Karapetyan A. O., Baev O. R., Ivanets T. Y.
Bulletin of Experimental Biology and Medicine
Vol.165, Issue4, P. 438-439
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1007/s10517-018-4188-5
Аннотация:
Changes in the levels of rennin, angiotensin II, and angiotensin (1–7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentration were observed during normal pregnancy (p=0.423). The level of angiotensin II increased during normal pregnancy from 9.7±1.2 to 14.7±1.9 pg/ml (p=0.019). On the contrary, angiotensin (1–7) concentration decreased from 771.1±44.2 to 390.7±13.9 pg/ml (p<0.001). The shift in the proportion between vasoconstrictor angiotensin II and vasodilaltor angiotensin (1–7) attests to high predisposition of pregnant women to hypertension-related complications. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
angiotensin (1–7); angiotensin II; pregnancy; renin; renin—angiotensin—aldosterone system
angiotensin II; angiotensinogen; angiotensin[1-7]; biochemical marker; dipeptidyl carboxypeptidase; renin; angiotensin I; angiotensin I (1-7); angiotensin II; peptide fragment; renin; vasoconstrictor agent; adult; Article; blood level; disease predisposition; female; gestation period; human; human experiment; hypertension; normal human; pregnancy; pregnant woman; blood; blood pressure; hypertension; middle aged; physiology; pregnancy; Adult; Angiotensin I; Angiotensin II; Blood Pressure; Female; Humans; Hypertension; Middle Aged; Peptide Fragments; Pregnancy; Renin; Vasoconstrictor Agents
Язык текста: Английский
ISSN: 1573-8221
Khlestova G. V.
Romanov A. Y.
Nizyaeva N. V.
Karapetyan A. O.
Baev O. R. Oleg Radomirovich 1957-
Ivanets T. Y.
Хлестова Г. В.
Романов А. Y.
Низяева Н. В.
Карапетян А. О.
Баев О. Р. Олег Радомирович 1957-
Иванец Т. Y.
Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications
Текст визуальный непосредственный
Bulletin of Experimental Biology and Medicine
Springer New York Consultants Bureau
Vol.165, Issue4 P. 438-439
2018
Статья
angiotensin (1–7) angiotensin II pregnancy renin renin—angiotensin—aldosterone system
angiotensin II angiotensinogen angiotensin[1-7] biochemical marker dipeptidyl carboxypeptidase renin angiotensin I angiotensin I (1-7) angiotensin II peptide fragment renin vasoconstrictor agent adult Article blood level disease predisposition female gestation period human human experiment hypertension normal human pregnancy pregnant woman blood blood pressure hypertension middle aged physiology pregnancy Adult Angiotensin I Angiotensin II Blood Pressure Female Humans Hypertension Middle Aged Peptide Fragments Pregnancy Renin Vasoconstrictor Agents
Changes in the levels of rennin, angiotensin II, and angiotensin (1–7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentration were observed during normal pregnancy (p=0.423). The level of angiotensin II increased during normal pregnancy from 9.7±1.2 to 14.7±1.9 pg/ml (p=0.019). On the contrary, angiotensin (1–7) concentration decreased from 771.1±44.2 to 390.7±13.9 pg/ml (p<0.001). The shift in the proportion between vasoconstrictor angiotensin II and vasodilaltor angiotensin (1–7) attests to high predisposition of pregnant women to hypertension-related complications. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.