The anxiolytic effects of atorvastatin and simvastatin on dietary-induced increase in homocysteine levels in rats
Mijailovic N., Selakovic D., Joksimovic J., Mihailovic V., Katanic J., Yakovlevich V., Nikolic T., Bolevich S., Zivkovic V., Pantic M., Rosic G.
Molecular and Cellular Biochemistry
Vol.452, Issue1-2, P. 199-217
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s11010-018-3425-6
Аннотация:
The aim of this study was to evaluate the effects of atorvastatin and simvastatin on behavioral manifestations that followed hyperhomocysteinemia induced by special dietary protocols enriched in methionine and deficient in B vitamins (B6, B9, B12) by means of alterations in anxiety levels in rats. Simultaneously, we investigated the alterations of oxidative stress markers in rat hippocampus induced by applied dietary protocols. Furthermore, considering the well-known antioxidant properties of statins, we attempted to assess their impact on major markers of oxidative stress and their possible beneficial role on anxiety-like behavior effect in rats. The 4-week-old male Wistar albino rats were divided (eight per group) according to basic dietary protocols: standard chow, methionine-enriched, and methionine-enriched vitamins B (B6, B9, B12) deficient. Each dietary protocol (30 days) included groups with atorvastatin (3 mg/kg/day i.p.) and simvastatin (5 mg/kg/day i.p.). The behavioral test
Ключевые слова:
Anxiety; Atorvastatin; Homocysteine; Oxidative stress; Rats; Simvastatin
atorvastatin; catalase; cyanocobalamin; glutathione; homocysteine; methionine; pyridoxine; simvastatin; superoxide dismutase; vitamin B group; anxiolytic agent; atorvastatin; homocysteine; hypocholesterolemic agent; simvastatin; animal experiment; animal model; animal tissue; anxiety disorder; Article; controlled study; drug effect; elevated plus maze test; enzyme activity; hippocampal tissue; hyperhomocysteinemia; lipid peroxidation; male; nonhuman; open field test; oxidative stress; rat; tranquilizing activity; animal; animal behavior; anxiety disorder; diet; hyperhomocysteinemia; metabolism; Wistar rat; Animals; Anti-Anxiety Agents; Anticholesteremic Agents; Anxiety Disorders; Atorvastatin; Behavior, Animal; Diet; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Simvastatin
Язык текста: Английский
ISSN: 1573-4919
Mijailovic N.
Selakovic D.
Joksimovic J.
Mihailovic V.
Katanic J.
Yakovlevich V. Vladimir 1971-
Nikolic T.
Bolevich S. Sergej 1964-
Zivkovic V.
Pantic M.
Rosic G.
Мийаиловиc Н.
Селаковиc Д.
Йоксимовиc Й.
Михаиловиc В.
Катаниc Й.
Яковлевич В. Владимир 1971-
Николиc Т.
Болевич С. Сергей 1964-
Зивковиc В.
Пантиc М.
Росиc Г.
The anxiolytic effects of atorvastatin and simvastatin on dietary-induced increase in homocysteine levels in rats
Текст визуальный непосредственный
Molecular and Cellular Biochemistry
Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
Vol.452, Issue1-2 P. 199-217
2019
Статья
Anxiety Atorvastatin Homocysteine Oxidative stress Rats Simvastatin
atorvastatin catalase cyanocobalamin glutathione homocysteine methionine pyridoxine simvastatin superoxide dismutase vitamin B group anxiolytic agent atorvastatin homocysteine hypocholesterolemic agent simvastatin animal experiment animal model animal tissue anxiety disorder Article controlled study drug effect elevated plus maze test enzyme activity hippocampal tissue hyperhomocysteinemia lipid peroxidation male nonhuman open field test oxidative stress rat tranquilizing activity animal animal behavior anxiety disorder diet hyperhomocysteinemia metabolism Wistar rat Animals Anti-Anxiety Agents Anticholesteremic Agents Anxiety Disorders Atorvastatin Behavior, Animal Diet Homocysteine Hyperhomocysteinemia Lipid Peroxidation Male Oxidative Stress Rats Rats, Wistar Simvastatin
The aim of this study was to evaluate the effects of atorvastatin and simvastatin on behavioral manifestations that followed hyperhomocysteinemia induced by special dietary protocols enriched in methionine and deficient in B vitamins (B6, B9, B12) by means of alterations in anxiety levels in rats. Simultaneously, we investigated the alterations of oxidative stress markers in rat hippocampus induced by applied dietary protocols. Furthermore, considering the well-known antioxidant properties of statins, we attempted to assess their impact on major markers of oxidative stress and their possible beneficial role on anxiety-like behavior effect in rats. The 4-week-old male Wistar albino rats were divided (eight per group) according to basic dietary protocols: standard chow, methionine-enriched, and methionine-enriched vitamins B (B6, B9, B12) deficient. Each dietary protocol (30 days) included groups with atorvastatin (3 mg/kg/day i.p.) and simvastatin (5 mg/kg/day i.p.). The behavioral test