Аннотация:
Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environm
Ключевые слова:
Articular hyaline cartilage; Autologous chondrocyte implantation (ACI); Cell-based therapy; Matrix-induced autologous chondrocyte implantation (MACI); Micro-fracture; Mosaicplasty; Regenerative medicine approaches; Stem cells; Tissue-engineered constructs
bone morphogenetic protein 2; bone morphogenetic protein 4; corticosteroid; fibroblast growth factor 3; growth differentiation factor 5; hyaluronic acid; kruppel like factor 4; leukocyte antigen; Myc protein; octamer transcription factor 4; osteogenic protein 1; small interfering RNA; transcription factor Sox2; articular cartilage; cartilage degeneration; chondrocyte; chondroplasty; gene expression; gene therapy; human; hypoxia; induced pluripotent stem cell; intracellular signaling; microfracture; osteoarthritis; phase 2 clinical trial (topic); phase 3 clinical trial (topic); protein expression; regenerative medicine; Review; stem cell transplantation; three dimensional printing; thrombocyte rich plasma; tissue engineering; animal; chondrocyte; injuries; injury; joint capsule; metabolism; osteoarthritis; pathology; procedures; trends; Animals; Chondrocytes; Humans; Joint Capsule; Osteoarthritis; Tissue Engineering; Wounds and Injuries
Medvedeva E. V. Ekaterina Valeryevna 1987-
Ivukina E. A. Ekaterina Andreevna 1986-
Gornostaeva S. N. Svetlana Nikolaevna 1976-
Telpuhov V. I.
Ly'chagin A. V. Aleksej Vladimirovich 1975-
Timashev P. S. Petr Sergeevich 1978-
Chagin A. S. Andrej Stanislavovich 1976-
Медведева Е. В. Екатерина Валерьевна 1987-
Ивукина Е. А. Екатерина Андреевна 1986-
Горностаева С. Н. Светлана Николаевна 1976-
Телпухов В. И.
Лычагин А. В. Алексей Владимирович 1975-
Тимашев П. С. Петр Сергеевич 1978-
Чагин А. С. Андрей Станиславович 1976-
Repair of damaged articular cartilage: Current approaches and future directions
Текст визуальный непосредственный
International Journal of Molecular Sciences
Vol.19, Issue8 Num.2366
2018
Обзор
Articular hyaline cartilage Autologous chondrocyte implantation (ACI) Cell-based therapy Matrix-induced autologous chondrocyte implantation (MACI) Micro-fracture Mosaicplasty Regenerative medicine approaches Stem cells Tissue-engineered constructs
bone morphogenetic protein 2 bone morphogenetic protein 4 corticosteroid fibroblast growth factor 3 growth differentiation factor 5 hyaluronic acid kruppel like factor 4 leukocyte antigen Myc protein octamer transcription factor 4 osteogenic protein 1 small interfering RNA transcription factor Sox2 articular cartilage cartilage degeneration chondrocyte chondroplasty gene expression gene therapy human hypoxia induced pluripotent stem cell intracellular signaling microfracture osteoarthritis phase 2 clinical trial (topic) phase 3 clinical trial (topic) protein expression regenerative medicine Review stem cell transplantation three dimensional printing thrombocyte rich plasma tissue engineering animal chondrocyte injuries injury joint capsule metabolism osteoarthritis pathology procedures trends Animals Chondrocytes Humans Joint Capsule Osteoarthritis Tissue Engineering Wounds and Injuries
Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environm