Differences between cerebrovascular effects of 5-hydroxyadamantane-2-one, nimodipine and S-amlodipine nicotinate in the hemorrhagic and ischemic...
Мирзоян Р. С., Ган'шина Т. С., Ким Г. А., Курдюмов И. Н., Масленников Д. В., Курза Е. В., Горбунов А. А.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 5, С. 3-6
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.30906/0869-2092-2018-81-5-3-6
Аннотация:
The cerebrovascular effects of 5-hydroxyadamantane-2-one (100 mg/kg, i.v.), nimodipine (0.03 mg/kg, i.v.), and S-amlodi- pine nicotinate (0.1 rag/kg, i.v.) were compared and found to differ significantly. While G ABA-ergic 5-hydroxyadaman- tan-2-one and slow calcium channels blocker nimodipine cause a pronounced increase in cerebral blood supply under conditions of global transient ischemia of the brain, their activity in modeling hemorrhagic stroke is significantly lower. At the same time, S-amlodipine nicotinate equally improves cerebral circulation in both hemorrhagic and ischemic brain damage, i.e., the cerebrovascular effect of S-amlodipine nicotinate in the hemorrhagic stroke model is superior to that of nimodipine and 5-hydroxyadamantan-2-one. This is due to a distinguishing feature of the of S-amlodipine nicotinate action, which, in contrast to 5-hydroxyadamantan-2-one and nimodipine, has a binary vasodilating effect on cerebral vessels: (i) blocking slow calcium channels and (
Ключевые слова:
5-hydroxyadamantan-2-one; Cerebral circulation; Global transient ischemia of the brain; Hemorrhagic stroke model; Nimodipine; S-amlodipine nicotinate
5 hydroxyadamantane 2 one; adamantane derivative; nimodipine; s amlodipine nicotinate; unclassified drug; animal model; Article; brain blood vessel; brain circulation; brain damage; brain hemorrhage; brain ischemia; clinical feature; controlled study; drug effect; nonhuman; rat; vascularization
Язык текста: Русский
ISSN: 0869-2092
Мирзоян Р. С.
Ган'шина Т. С.
Ким Г. А.
Курдюмов И. Н.
Масленников Д. В.
Курза Е. В.
Горбунов А. А. Александр Анатольевич 1984-
Mirzoyan R. S.
Gan'shina T. S.
Kim G. A.
Kurdyumov I. N.
Maslennikov D. V.
Kurza E. V.
Gorbunov A. A. Aleksandr Anatolyevich 1984-
Differences between cerebrovascular effects of 5-hydroxyadamantane-2-one, nimodipine and S-amlodipine nicotinate in the hemorrhagic and ischemic model damage of rat brain
Differences between cerebrovascular effects of 5-hydroxyadamantane-2-one, nimodipine and S-amlodipine nicotinate in the hemorrhagic and ischemic...
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 5 С. 3-6
2018
Статья
5-hydroxyadamantan-2-one Cerebral circulation Global transient ischemia of the brain Hemorrhagic stroke model Nimodipine S-amlodipine nicotinate
5 hydroxyadamantane 2 one adamantane derivative nimodipine s amlodipine nicotinate unclassified drug animal model Article brain blood vessel brain circulation brain damage brain hemorrhage brain ischemia clinical feature controlled study drug effect nonhuman rat vascularization
The cerebrovascular effects of 5-hydroxyadamantane-2-one (100 mg/kg, i.v.), nimodipine (0.03 mg/kg, i.v.), and S-amlodi- pine nicotinate (0.1 rag/kg, i.v.) were compared and found to differ significantly. While G ABA-ergic 5-hydroxyadaman- tan-2-one and slow calcium channels blocker nimodipine cause a pronounced increase in cerebral blood supply under conditions of global transient ischemia of the brain, their activity in modeling hemorrhagic stroke is significantly lower. At the same time, S-amlodipine nicotinate equally improves cerebral circulation in both hemorrhagic and ischemic brain damage, i.e., the cerebrovascular effect of S-amlodipine nicotinate in the hemorrhagic stroke model is superior to that of nimodipine and 5-hydroxyadamantan-2-one. This is due to a distinguishing feature of the of S-amlodipine nicotinate action, which, in contrast to 5-hydroxyadamantan-2-one and nimodipine, has a binary vasodilating effect on cerebral vessels: (i) blocking slow calcium channels and (