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Effects of ischemic and proton pump inhibitors preconditioning on oxidative stress of isolated rat heart [Efekti ishemijskog i prekondicioniranja...

Jeremic N., Zivkovic V., Srejovic I., Jeremic J., Petkovic A., Bradic J., Yakovlevich V.
Serbian Journal of Experimental and Clinical Research
Vol.19, Issue2, P. 131-139
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2 -), superoxide anion radicals (O2 -), index of lipid peroxidation (TBARS) and hydrogen peroxide (H2O2) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors. Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism. Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia. © 2018, University of Kragujevac, Faculty of Science. All rights reserved.
Ключевые слова:
Ischemic preconditioning; Myocardial infarction; Oxidative stress; Proton pump inhibitors
biological marker; hydrogen peroxide; lansoprazole; nitrite; omeprazole; pantoprazole; superoxide; Article; clinical practice; controlled study; coronary artery blood flow; heart muscle injury; heart muscle ischemia; ischemic preconditioning; lipid peroxidation; male; nonhuman; oxidative stress; rat; reperfusion injury
Язык текста: Английский
ISSN: 1820-8665
Jeremic N.
Zivkovic V.
Srejovic I.
Jeremic J.
Petkovic A.
Bradic J.
Yakovlevich V. Vladimir 1971-
Йеремиc Н.
Зивковиc В.
Срейовиc И.
Йеремиc Й.
Петковиc А.
Брадиc Й.
Яковлевич В. Владимир 1971-
Effects of ischemic and proton pump inhibitors preconditioning on oxidative stress of isolated rat heart [Efekti ishemijskog i prekondicioniranja inhibitorima protonske pumpe na oksidacioni stres izolovanog srca pacova]
Effects of ischemic and proton pump inhibitors preconditioning on oxidative stress of isolated rat heart [Efekti ishemijskog i prekondicioniranja...
Текст визуальный непосредственный
Serbian Journal of Experimental and Clinical Research
Vol.19, Issue2 P. 131-139
2018
Статья
Ischemic preconditioning Myocardial infarction Oxidative stress Proton pump inhibitors
biological marker hydrogen peroxide lansoprazole nitrite omeprazole pantoprazole superoxide Article clinical practice controlled study coronary artery blood flow heart muscle injury heart muscle ischemia ischemic preconditioning lipid peroxidation male nonhuman oxidative stress rat reperfusion injury
Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2 -), superoxide anion radicals (O2 -), index of lipid peroxidation (TBARS) and hydrogen peroxide (H2O2) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors. Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism. Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia. © 2018, University of Kragujevac, Faculty of Science. All rights reserved.