Аннотация:
The lecture deals with treatment of patients with CIN associated with papillomavirus infection (HPVI). The issues of epidemiology, diagnosis and treatment of CIN are discussed. Emphasis is put on a complex approach to treating patients with HPVI-associated CIN. Special attention is paid to studying the mechanisms of dysregulation of immune response during the period of human papillomavirus virus (HPV) persistence, which promotes immune suppression and is considered to be a necessary precondition for progression of HPV-associated cancer. Based on analysis of literature sources, the authors show that high oncogenic risk E6 and E7 HPV types interact with key proteins of interferon signalling pathway, inhibiting its production. This accounts for insufficient effectiveness of preparations of pure interferons and their inductors for treatment of HPV infection. From the pathogenetic positions, the use of inosine pranobex as a medication in complex therapy would be appropriate, since it ensure
Давыдов А. И. Александр Ильгизирович 1961-
Шахламова М. Н. Марина Николаевна 1959-
Лебедев В. А. Владимир Александрович 1955-
Davy'dov A. I. Aleksandr Il`gizirovich 1961-
Shakhlamova M. N. Marina Nikolaevna 1959-
Lebedev V. A. Vladimir Aleksandrovich 1955-
Cervical intraepithelial neoplasia associated with papillomavirus infection: Pathogenetic rationale of treating patients during the reproductive period
Cervical intraepithelial neoplasia associated with papillomavirus infection: Pathogenetic rationale of treating patients during the reproductive...
Текст визуальный непосредственный
Вопросы гинекологии, акушерства и перинатологии
ООО "Издательство "Династия"
Т. 17, Вып. 3 С. 66-72
2018
Статья
Cervical dysplasia CIN E6 and E7 Inosine pranobex Interferons Oncoproteins E5
The lecture deals with treatment of patients with CIN associated with papillomavirus infection (HPVI). The issues of epidemiology, diagnosis and treatment of CIN are discussed. Emphasis is put on a complex approach to treating patients with HPVI-associated CIN. Special attention is paid to studying the mechanisms of dysregulation of immune response during the period of human papillomavirus virus (HPV) persistence, which promotes immune suppression and is considered to be a necessary precondition for progression of HPV-associated cancer. Based on analysis of literature sources, the authors show that high oncogenic risk E6 and E7 HPV types interact with key proteins of interferon signalling pathway, inhibiting its production. This accounts for insufficient effectiveness of preparations of pure interferons and their inductors for treatment of HPV infection. From the pathogenetic positions, the use of inosine pranobex as a medication in complex therapy would be appropriate, since it ensure