Worldwide variation in human milk metabolome: Indicators of breast physiology and maternal lifestyle?
Gay M. C. L., Koleva P. T., Slupsky C. M., du T. E., Eggesbo M., Johnson C. C., Wegienka G., Shimojo N., Campbell D. E., Prescott S. L., Munblit D. B., Geddes D. T., Kozyrskyj A. L., Dahl C., Haynes A., Hsu P., Mackay C., Penders J., Renz H., Thijs C., West C.
Nutrients
Vol.10, Issue9, Num.1151
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother’s diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of mil
Ключевые слова:
Human milk; Lactation; Milk metabolites; Milk metabolomics
2 oxoglutaric acid; acetone; alanine; betaine; biological marker; choline; citric acid; creatine; creatine phosphate; creatinine; fatty acid; fucose; glucose; glutamic acid; glutamine; glycerophosphorylcholine; glycine; isoleucine; lactic acid; lactose; leucine; methanol; octanoic acid; phosphorylcholine; pyruvic acid; succinic acid; valine; amino acid; carbohydrate; milk protein; adult; Article; atopy; breast feeding; breast milk; diet; ethnicity; female; human; infant; intestine flora; lifestyle; major clinical study; male; mastitis; metabolome; metabolomics; milk production; nuclear magnetic resonance imaging; obesity; partial least squares regression; proton nuclear magnetic resonance; quality control; ancestry group; Australia; breast; breast milk; chemistry; energy metabolism; ethnic group; hypersensitivity; Japan; metabolism; metabolome; mother; Norway; nuclear magnetic resonance spectroscopy; physiology; United States; Amino Acids; Australia; Breast; Carbohydrates; Choline; Con
Язык текста: Английский
ISSN: 2072-6643
Gay M. C. L.
Koleva P. T.
Slupsky C. M.
du T. E. Toit E.
Eggesbo M.
Johnson C. C.
Wegienka G.
Shimojo N.
Campbell D. E.
Prescott S. L.
Munblit D. B. Daniil Borisovich 1980-
Geddes D. T.
Kozyrskyj A. L.
Dahl C.
Haynes A.
Hsu P.
Mackay C.
Penders J.
Renz H.
Thijs C.
West C.
Гай М. C. Л.
Колева П. Т.
Слупскy C. М.
ду Т. Е. Тоит Е.
Еггесбо М.
Йохнсон C. C.
Wегиенка Г.
Шимойо Н.
Cампбелл Д. Е.
Пресcотт С. Л.
Мунблит Д. Б. Даниил Борисович 1980-
Геддес Д. Т.
Козyрскyй А. Л.
Дахл C.
Хайнес А.
Хсу П.
Маcкай C.
Пендерс Й.
Ренз Х.
Тхийс C.
Wест C.
Worldwide variation in human milk metabolome: Indicators of breast physiology and maternal lifestyle?
Текст визуальный непосредственный
Nutrients
Vol.10, Issue9 Num.1151
2018
Статья
Human milk Lactation Milk metabolites Milk metabolomics
2 oxoglutaric acid acetone alanine betaine biological marker choline citric acid creatine creatine phosphate creatinine fatty acid fucose glucose glutamic acid glutamine glycerophosphorylcholine glycine isoleucine lactic acid lactose leucine methanol octanoic acid phosphorylcholine pyruvic acid succinic acid valine amino acid carbohydrate milk protein adult Article atopy breast feeding breast milk diet ethnicity female human infant intestine flora lifestyle major clinical study male mastitis metabolome metabolomics milk production nuclear magnetic resonance imaging obesity partial least squares regression proton nuclear magnetic resonance quality control ancestry group Australia breast breast milk chemistry energy metabolism ethnic group hypersensitivity Japan metabolism metabolome mother Norway nuclear magnetic resonance spectroscopy physiology United States Amino Acids Australia Breast Carbohydrates Choline Con
Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother’s diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of mil