Аннотация:
Sanguinarin is a plant alkaloid with a wide spectrum of biological activity. The effectiveness of sanguinarin can be increased by its integration into liposomal nanoparticles. The aim of this study was to obtain and purify the pegylated liposome sanguinarine, to study its properties, as well as antitumor and antimicrobial activity in vitro. Pegylated liposome nanoparticles containing sanguinarinewere obtained. The size of the liposomes was 61.8±5.7 nm; the effectiveness of the inclusion of sanguinarine in liposomes was 82.3±4.9[%]. The article studies the release of sanguinarin from liposome particles and demonstrates its prolonged nature. An in vitro study showed that liposomal sanguinarine exhibited dose-dependent cytotoxic activity against tumor cells of MCF-7 (12.8 μM), L1210 (17.4 μM), A431 (18.67 μM) and HepG2 (20.7 μM). The antimicrobial effect of the liposome form of the drug was established for Gram-positive (B.subtilis ATC 6633 and B.coagulans 429) and Gram-negative (E.coli ATC
Луценко С. В. Сергей Викторович 1957-
Громовых Т. И. Татьяна Ильинична 1950-
Каширин В. В. Владимир Валентинович 1993-
Куряков В. Н.
Баранова А. А.
Садyкова В. С.
Фельдман Н. Б. Наталия Борисовна 1969-
Lutsenko S. V. Sergej Viktorovich 1957-
Gromovy'kh T. I. Tat`yana Il`inichna 1950-
Kashirin V. V. Vladimir Valentinovich 1993-
Kuryakov V. N.
Baranova A. A.
Sadykova V. S.
Fel`dman N. B. Nataliya Borisovna 1969-
In Vitro Study of Antitumor and Antimicrobial Activity of a Preparation of Pegylated Liposomes with Sanguinarine
Текст визуальный непосредственный
Антибиотики и химиотерапия
Издательство ОКИ
Т. 63, Вып. 3-4 С. 3-7
2018
Статья
Antimicrobial activity Antitumor activity Pegylated liposomes Sanguinarin
Sanguinarin is a plant alkaloid with a wide spectrum of biological activity. The effectiveness of sanguinarin can be increased by its integration into liposomal nanoparticles. The aim of this study was to obtain and purify the pegylated liposome sanguinarine, to study its properties, as well as antitumor and antimicrobial activity in vitro. Pegylated liposome nanoparticles containing sanguinarinewere obtained. The size of the liposomes was 61.8±5.7 nm; the effectiveness of the inclusion of sanguinarine in liposomes was 82.3±4.9[%]. The article studies the release of sanguinarin from liposome particles and demonstrates its prolonged nature. An in vitro study showed that liposomal sanguinarine exhibited dose-dependent cytotoxic activity against tumor cells of MCF-7 (12.8 μM), L1210 (17.4 μM), A431 (18.67 μM) and HepG2 (20.7 μM). The antimicrobial effect of the liposome form of the drug was established for Gram-positive (B.subtilis ATC 6633 and B.coagulans 429) and Gram-negative (E.coli ATC