Markers of systemic inflammation in the pathogenesis of functional dyspesia
Babaeva A. R., Osadchuk M. A., Vidiker R. V., Solodenkova K. S., Shulkina S. G., Trushin M. V.
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue8, P. 1943-1946
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
The article presents the results of research into the role of systemic inflammation in the pathogenesis and clinical presentation of functional dyspepsia. Elevated serum concentrations of pro-inflammatory cytokines, including TNF-α, IL-1ß, IL-6, IL-8, and low IL-10 levels have been reported in patients with functional dyspepsia. Serum cytokine profiles have been shown to correlate positively with the most pronounced clinical sign of functional dyspepsia, epigastric pain. The serum levels of pro-inflammatory cytokines, TNF-α, IL-1ß and IL-6, were significantly higher in patients with functional dyspepsia and Helicobacter pylori infection. Elevated levels of TNF-α, IL-1ß and IL-8 have been shown to correlate with functional dyspepsia and postprandial distress syndrome, and high concentrations of IL-1β were indicative of functional dyspepsia and epigastric pain syndrome. The expression of pro-inflammatory cytokines in the functional dyspepsia group was much less pronounced than in patient
Ключевые слова:
Cytokines; Functional dyspepsia; Systemic inflammation
interleukin 10; interleukin 1beta; interleukin 6; interleukin 8; tumor necrosis factor; adult; Article; comparative study; controlled study; cytokine release; cytokine storm; digestive system inflammation; distress syndrome; dyspepsia; epigastric pain; female; Helicobacter infection; Helicobacter pylori; human; major clinical study; male; pathogenesis; peptic ulcer; postprandial state; visual analog scale
Язык текста: Английский
ISSN: 0975-1459
Babaeva A. R.
Osadchuk M. A. Mikhail Alekseevich 1951-
Vidiker R. V.
Solodenkova K. S. Karina Sergeevna 1981-
Shulkina S. G.
Trushin M. V.
Бабаева А. Р.
Осадчук М. А. Михаил Алексеевич 1951-
Видикер Р. В.
Солоденкова К. С. Карина Сергеевна 1981-
Шулкина С. Г.
Трушин М. В.
Markers of systemic inflammation in the pathogenesis of functional dyspesia
Текст визуальный непосредственный
Journal of Pharmaceutical Sciences and Research
Vol.10, Issue8 P. 1943-1946
2018
Статья
Cytokines Functional dyspepsia Systemic inflammation
interleukin 10 interleukin 1beta interleukin 6 interleukin 8 tumor necrosis factor adult Article comparative study controlled study cytokine release cytokine storm digestive system inflammation distress syndrome dyspepsia epigastric pain female Helicobacter infection Helicobacter pylori human major clinical study male pathogenesis peptic ulcer postprandial state visual analog scale
The article presents the results of research into the role of systemic inflammation in the pathogenesis and clinical presentation of functional dyspepsia. Elevated serum concentrations of pro-inflammatory cytokines, including TNF-α, IL-1ß, IL-6, IL-8, and low IL-10 levels have been reported in patients with functional dyspepsia. Serum cytokine profiles have been shown to correlate positively with the most pronounced clinical sign of functional dyspepsia, epigastric pain. The serum levels of pro-inflammatory cytokines, TNF-α, IL-1ß and IL-6, were significantly higher in patients with functional dyspepsia and Helicobacter pylori infection. Elevated levels of TNF-α, IL-1ß and IL-8 have been shown to correlate with functional dyspepsia and postprandial distress syndrome, and high concentrations of IL-1β were indicative of functional dyspepsia and epigastric pain syndrome. The expression of pro-inflammatory cytokines in the functional dyspepsia group was much less pronounced than in patient