The forensic medical estimation of the biological age of the corpse based on the morphological changes in the skin
Пиголкин Ю. И., Должанскy О. В., Золотенкова Г. В., Аметрин М. Д., Золотенков Д. Д.
Судебно-медицинская экспертиза
Т. 61, Вып. 4, С. 32-34
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.17116/sudmed201861432
Аннотация:
The objective of the present work was the immunohistochemical evaluation of the age-related dynamics of apoptosis-associated proteins contained in the human skin epidermis. We studied the samples of skin tissues obtained during the forensic medical expertises of 100 corpses of the subjects who died in the consequence of acute blood loss in the absence of injuries or pathological changes in the skin (56 men and 44 women at the age varying from 5 to 85 years). The results of this study give evidence that the histoimmunological investigations of the skin tissues can be carried out with the use of the mmunohistochemical Ki67, bcl-2, and p53 markers for the more accurate determination of the biological age of the deceased subjects. The quantitative characteristics thus obtained serve as reliable indicators of the chronic changes in the skin and can be used as the components of the combined diagnostic procedures. © 2018, Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
Age-related changes in the skin; Biological age; Immunohistochemical markers
Ki 67 antigen; MKI67 protein, human; protein bcl 2; protein p53; adolescent; adult; age; cutaneous parameters; female; forensic pathology; human; male; metabolism; middle aged; molecular pathology; pathology; preschool child; procedures; skin; very elderly; Adolescent; Adult; Age Factors; Aged, 80 and over; Child, Preschool; Female; Forensic Pathology; Humans; Ki-67 Antigen; Male; Middle Aged; Pathology, Molecular; Proto-Oncogene Proteins c-bcl-2; Skin; Skin Aging; Tumor Suppressor Protein p53
Язык текста: Русский
ISSN: 2309-5326
Пиголкин Ю. И. Юрий Иванович 1952-
Должанскy О. В.
Золотенкова Г. В. Галина Вячеславовна 1973-
Аметрин М. Д.
Золотенков Д. Д.
Pigolkin Yu. I. Yurij Ivanovich 1952-
Dolzhansky O. V.
Zolotenkova G. V. Galina Vyacheslavovna 1973-
Ametrin M. D.
Zolotenkov D. D.
The forensic medical estimation of the biological age of the corpse based on the morphological changes in the skin
Текст визуальный непосредственный
Судебно-медицинская экспертиза
Издательство Медиа Сфера
Т. 61, Вып. 4 С. 32-34
2018
Статья
Age-related changes in the skin Biological age Immunohistochemical markers
Ki 67 antigen MKI67 protein, human protein bcl 2 protein p53 adolescent adult age cutaneous parameters female forensic pathology human male metabolism middle aged molecular pathology pathology preschool child procedures skin very elderly Adolescent Adult Age Factors Aged, 80 and over Child, Preschool Female Forensic Pathology Humans Ki-67 Antigen Male Middle Aged Pathology, Molecular Proto-Oncogene Proteins c-bcl-2 Skin Skin Aging Tumor Suppressor Protein p53
The objective of the present work was the immunohistochemical evaluation of the age-related dynamics of apoptosis-associated proteins contained in the human skin epidermis. We studied the samples of skin tissues obtained during the forensic medical expertises of 100 corpses of the subjects who died in the consequence of acute blood loss in the absence of injuries or pathological changes in the skin (56 men and 44 women at the age varying from 5 to 85 years). The results of this study give evidence that the histoimmunological investigations of the skin tissues can be carried out with the use of the mmunohistochemical Ki67, bcl-2, and p53 markers for the more accurate determination of the biological age of the deceased subjects. The quantitative characteristics thus obtained serve as reliable indicators of the chronic changes in the skin and can be used as the components of the combined diagnostic procedures. © 2018, Media Sphera Publishing Group. All rights reserved.