Manifestation of graves’ disease, resulting from radiosurgical treatment of acromegaly, in a patient with panhypopituitarism
Астафьева Л. И., Калинин П. Л., Киениа Т. А., Фадеев В. В.
Проблемы эндокринологии
Т. 65, Вып. 2, С. 101-106
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
Cases of thyrotoxicosis associated with a previous case of secondary hypothyroidism are extremely rare. This article presents a rare clinical case of Graves’ disease manifestation in a patient with secondary hypothyroidism after radiosurgical treatment of acromegaly. A 38-year old woman presented with acromegaly and endo-supra-laterosellar pituitary adenoma. After non-radical removal of the pituitary adenoma, radiosurgical treatment of the of the residual tissue of the pituitary tumor in the cavernous sinus area was performed. After 14 months of radiation therapy, the acromegaly was in remission; after 24 months of radiation therapy, panhypopituitarism developed (secondary hypothyroidism, adrenal insufficiency, hypogonadism, and growth hormone deficiency). Furthermore, 1.5 years after the panhypopituitarism was diagnosed, the manifestation of Graves’ disease was also noted, requiring thyrostatic and radioactive iodine treatments. Diagnostic criteria for secondary hypothyroidism are low
Ключевые слова:
Acromegaly; Case report; Graves’ disease; Panhypopituitarism; Radiosurgical treatment; Secondary hypothyroidism; Thyrotoxicosis
antithyroid agent; growth hormone; levothyroxine; liothyronine; radioactive iodine; thyrotropin; thyrotropin receptor antibody; thyroxine; acromegaly; adrenal insufficiency; adult; Article; case report; cavernous sinus; clinical article; free liothyronine index; free thyroxine index; Graves disease; growth hormone deficiency; human; hypogonadism; hypophysis adenoma; hypopituitarism; hypothyroidism; male; radiosurgery; remission; thyrotoxicosis
Язык текста: Русский
ISSN: 2308-1430
Астафьева Л. И.
Калинин П. Л.
Киениа Т. А.
Фадеев В. В. Валентин Викторович 1973-
Astafyeva L. I.
Kalinin P. L.
Kienia T. A.
Fadeev V. V. Valentin Viktorovich 1973-
Manifestation of graves’ disease, resulting from radiosurgical treatment of acromegaly, in a patient with panhypopituitarism
Текст визуальный непосредственный
Проблемы эндокринологии
Издательство Медиа Сфера
Т. 65, Вып. 2 С. 101-106
2019
Статья
Acromegaly Case report Graves’ disease Panhypopituitarism Radiosurgical treatment Secondary hypothyroidism Thyrotoxicosis
antithyroid agent growth hormone levothyroxine liothyronine radioactive iodine thyrotropin thyrotropin receptor antibody thyroxine acromegaly adrenal insufficiency adult Article case report cavernous sinus clinical article free liothyronine index free thyroxine index Graves disease growth hormone deficiency human hypogonadism hypophysis adenoma hypopituitarism hypothyroidism male radiosurgery remission thyrotoxicosis
Cases of thyrotoxicosis associated with a previous case of secondary hypothyroidism are extremely rare. This article presents a rare clinical case of Graves’ disease manifestation in a patient with secondary hypothyroidism after radiosurgical treatment of acromegaly. A 38-year old woman presented with acromegaly and endo-supra-laterosellar pituitary adenoma. After non-radical removal of the pituitary adenoma, radiosurgical treatment of the of the residual tissue of the pituitary tumor in the cavernous sinus area was performed. After 14 months of radiation therapy, the acromegaly was in remission; after 24 months of radiation therapy, panhypopituitarism developed (secondary hypothyroidism, adrenal insufficiency, hypogonadism, and growth hormone deficiency). Furthermore, 1.5 years after the panhypopituitarism was diagnosed, the manifestation of Graves’ disease was also noted, requiring thyrostatic and radioactive iodine treatments. Diagnostic criteria for secondary hypothyroidism are low