Levels of growth factors and iga in the colostrum of women from Burundi and Italy
Munblit D. B., Abrol P., Sheth S., Chow L. Y., Khaleva E., Asmanov A., Lauriola S., Padovani E. M., Komber`yati P., Boner A. L., Warner J. O., Boyle R. J., Peroni D. G.
Nutrients
Vol.10, Issue9, Num.1216
Опубликовано: 2018
Тип ресурса: Статья
Аннотация:
Colostrum is produced in the first days postpartum. It is a known source of immune mediators for a newborn within the first week of life. Although it is still unclear if colostrum composition varies between populations, recent data suggest differences. Hepatocyte growth factor (HGF); transforming growth factor-β (TGF-β) 1, 2, and 3; and immunoglobulin A (IgA) are key immunological components of colostrum that stimulate neonatal gastrointestinal and immune system development. We aimed to investigate the differences in the concentration between immune markers in the colostrum of mothers living in Burundi and Italy, and to identify the factors associated with differences. In this cross-sectional birth cohort study, a total of 99 colostrum samples from Burundian (n = 23) and Italian (n = 76) women were collected at 0 to 6 days postpartum. A clinical chemistry analyser was used for IgA quantification and electro-chemiluminescence, for HGF and TGFβ1-3 assessment. A univariate analysis and mu
Ключевые слова:
Breast milk; Colostrum; Geographical location; Growth factors; HGF; Human milk; IgA; TGF-β
growth factor; immunoglobulin A; scatter factor; transforming growth factor beta1; transforming growth factor beta2; transforming growth factor beta3; HGF protein, human; immunoglobulin A; immunologic factor; scatter factor; transforming growth factor beta; transforming growth factor beta2; adult; Article; breast milk; cohort analysis; colostrum; cross-sectional study; electrochemiluminescence; female; gestational age; human; immune response; infant; male; perinatal period; questionnaire; breast; breast feeding; Burundi; colostrum; developing country; hypersensitivity; immunology; Italy; lactation; metabolism; newborn; pregnancy; puerperium; young adult; Adult; Breast; Breast Feeding; Burundi; Cohort Studies; Colostrum; Cross-Sectional Studies; Developed Countries; Developing Countries; Female; Hepatocyte Growth Factor; Humans; Hypersensitivity; Immunoglobulin A; Immunologic Factors; Infant, Newborn; Italy; Lactation; Milk, Human; Postpartum Period; Pregnancy; Transforming Growth Facto
Язык текста: Английский
ISSN: 2072-6643
Munblit D. B. Daniil Borisovich 1980-
Abrol P.
Sheth S.
Chow L. Y.
Khaleva E.
Asmanov A.
Lauriola S.
Padovani E. M.
Komber`yati P. Paskuale 1988-
Boner A. L.
Warner J. O.
Boyle R. J.
Peroni D. G.
Мунблит Д. Б. Даниил Борисович 1980-
Аброл П.
Шетх С.
Чоw Л. Y.
Халева Е.
Асманов А.
Лауриола С.
Падовани Е. М.
Комберьяти П. Паскуале 1988-
Бонер А. Л.
Wарнер Й. О.
Боyле Р. Й.
Перони Д. Г.
Levels of growth factors and iga in the colostrum of women from Burundi and Italy
Текст визуальный непосредственный
Nutrients
Vol.10, Issue9 Num.1216
2018
Статья
Breast milk Colostrum Geographical location Growth factors HGF Human milk IgA TGF-β
growth factor immunoglobulin A scatter factor transforming growth factor beta1 transforming growth factor beta2 transforming growth factor beta3 HGF protein, human immunoglobulin A immunologic factor scatter factor transforming growth factor beta transforming growth factor beta2 adult Article breast milk cohort analysis colostrum cross-sectional study electrochemiluminescence female gestational age human immune response infant male perinatal period questionnaire breast breast feeding Burundi colostrum developing country hypersensitivity immunology Italy lactation metabolism newborn pregnancy puerperium young adult Adult Breast Breast Feeding Burundi Cohort Studies Colostrum Cross-Sectional Studies Developed Countries Developing Countries Female Hepatocyte Growth Factor Humans Hypersensitivity Immunoglobulin A Immunologic Factors Infant, Newborn Italy Lactation Milk, Human Postpartum Period Pregnancy Transforming Growth Facto
Colostrum is produced in the first days postpartum. It is a known source of immune mediators for a newborn within the first week of life. Although it is still unclear if colostrum composition varies between populations, recent data suggest differences. Hepatocyte growth factor (HGF); transforming growth factor-β (TGF-β) 1, 2, and 3; and immunoglobulin A (IgA) are key immunological components of colostrum that stimulate neonatal gastrointestinal and immune system development. We aimed to investigate the differences in the concentration between immune markers in the colostrum of mothers living in Burundi and Italy, and to identify the factors associated with differences. In this cross-sectional birth cohort study, a total of 99 colostrum samples from Burundian (n = 23) and Italian (n = 76) women were collected at 0 to 6 days postpartum. A clinical chemistry analyser was used for IgA quantification and electro-chemiluminescence, for HGF and TGFβ1-3 assessment. A univariate analysis and mu