Characteristics of biomarkers of the toxicity of okadaic acid in vivo
Багрянцева О. В., Гмошинскy И. В., Евстратова А. Д., Трушина Е. Н., Мустафина О. К., Сото К. С., Ригер Н. А., Шyмакова А. А., Хотимченко С. А.
Гигиена и санитария
Т. 97, Вып. 4, С. 355-361
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.18821/0016-9900-2018-97-4-355-361
Аннотация:
Okadaic acid (OA) is relating to the number of seafood toxins causing diarrhea. At the present time, there was determined the toxicity index of OA; the main target molecules of its action, its role as a promoter of tumor processes and apoptosis have been investigated. However, in the available literature, data on the toxicokinetics of OA and molecular biomarkers of its action for warm-blooded animals are practically absent. The purpose of this work was to determine biomarkers of toxicity of OA in experiments in vivo and ex vivo. The experiment was performed on 74 male Wistar rats with an initial body weight of 100 ± 10 g. In the work, there was used a solution of OA in methanol, produced by “FermentecLtd.” (Israel). Prior to the studies, methanol was removed from the preparation. To obtain working dilutions of the toxin, aliquots of the alcoholic OA solution with a concentration of 10 ppm were diluted with a sterile solution of 0.15M NaCl to obtain solutions with a concentration of OA
Ключевые слова:
Glutathione peroxidase; Malonic dialdehyde; Markers of toxic action; Okadaic acid; Thiol compounds
Язык текста: Русский
ISSN: 2412-0650
Багрянцева О. В. Ольга Викторовна 1960-
Гмошинскy И. В.
Евстратова А. Д.
Трушина Е. Н.
Мустафина О. К.
Сото К. С. Х.С.
Ригер Н. А.
Шyмакова А. А.
Хотимченко С. А. Сергей Анатольевич 1953-
Bagryantseva O. V. Ol`ga Viktorovna 1960-
Gmoshinsky I. V.
Evstratova A. D.
Trushina E. N.
Mustafina O. K.
Soto K. S. Kh.S.
Riger N. A.
Shymakova A. A.
Khotimchenko S. A. Sergej Anatolyevich 1953-
Characteristics of biomarkers of the toxicity of okadaic acid in vivo
Текст визуальный непосредственный
Гигиена и санитария
Издательство "Медицина"
Т. 97, Вып. 4 С. 355-361
2018
Статья
Glutathione peroxidase Malonic dialdehyde Markers of toxic action Okadaic acid Thiol compounds
Okadaic acid (OA) is relating to the number of seafood toxins causing diarrhea. At the present time, there was determined the toxicity index of OA; the main target molecules of its action, its role as a promoter of tumor processes and apoptosis have been investigated. However, in the available literature, data on the toxicokinetics of OA and molecular biomarkers of its action for warm-blooded animals are practically absent. The purpose of this work was to determine biomarkers of toxicity of OA in experiments in vivo and ex vivo. The experiment was performed on 74 male Wistar rats with an initial body weight of 100 ± 10 g. In the work, there was used a solution of OA in methanol, produced by “FermentecLtd.” (Israel). Prior to the studies, methanol was removed from the preparation. To obtain working dilutions of the toxin, aliquots of the alcoholic OA solution with a concentration of 10 ppm were diluted with a sterile solution of 0.15M NaCl to obtain solutions with a concentration of OA