Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunosuppressive therapy
Колоскова Н. Н., Nikitina E. A., Zakharevich V. M., Муминов И. И., Cван В. С., Попцов В. Н., Ахмадзаи Р. Л., Изотов Д. А., Шевченко А. О.
Вестник трансплантологии и искусственных органов
Т. 20, Вып. 3, С. 70-74
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.15825/1995-1191-2018-3-70-74
Аннотация:
Heart transplantation is the «gold standard» of treatment severe heart failure. Patient survival after heart transplantation has improved dramatically since the availability of calcineurin inhibitor (CNIs). However, nephrotoxicity of CNIs has been largely responsible for the progressive development of renal dysfunction and reduces long-term patient survival. Use mTOR inhibitor in immunosuppressive therapy may improve renal function when everolimus is administered associated with a progressive reduction of CNIs. The purpose of our report is to demonstrate the successful case of conversion of the recipient after heart transplantation to everolimus and to evaluate the effectiveness of this drug during the observation year after heart transplantation. © 2018 Russian Transplant Society. All rights reserved.
Ключевые слова:
Heart transplantation; Immunosuppressive therapy; MTOR inhibitor; Nephrotoxicity of calcineurin inhibitor; Renal dysfunction; Еverolimus
Язык текста: Русский
ISSN: 2412-6160
Колоскова Н. Н.
Nikitina E. A.
Zakharevich V. M.
Муминов И. И.
Cван В. С.
Попцов В. Н. Виталий Николаевич 0001-
Ахмадзаи Р. Л.
Изотов Д. А.
Шевченко А. О. Алексей Олегович 1972-
Koloskova N. N.
Никитина Е. А.
Захаревич В. М.
Muminov I. I.
Cvan V. S.
Poptsov V. N. Vitalij Nikolaevich 0001-
Ahmadzai R. L.
Izotov D. A.
Shevchenko A. O. Aleksej Olegovich 1972-
Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunosuppressive therapy
Текст визуальный непосредственный
Вестник трансплантологии и искусственных органов
Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова
Т. 20, Вып. 3 С. 70-74
2018
Статья
Heart transplantation Immunosuppressive therapy MTOR inhibitor Nephrotoxicity of calcineurin inhibitor Renal dysfunction Еverolimus
Heart transplantation is the «gold standard» of treatment severe heart failure. Patient survival after heart transplantation has improved dramatically since the availability of calcineurin inhibitor (CNIs). However, nephrotoxicity of CNIs has been largely responsible for the progressive development of renal dysfunction and reduces long-term patient survival. Use mTOR inhibitor in immunosuppressive therapy may improve renal function when everolimus is administered associated with a progressive reduction of CNIs. The purpose of our report is to demonstrate the successful case of conversion of the recipient after heart transplantation to everolimus and to evaluate the effectiveness of this drug during the observation year after heart transplantation. © 2018 Russian Transplant Society. All rights reserved.