Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice
Kiser D. P., Popp S., Schmitt-Böhrer A. G., Strekalova T. V., van d. H. D. L., Lesh K. Yu., Rivero O.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Vol.89, P. 158-168
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.pnpbp.2018.08.010
Аннотация:
Objective: Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the presynaptic compartment of inhibitory GABAergic synapses in the hippocampus and Cdh13 knockout mice show an increased inhibitory drive onto hippocampal CA1 pyramidal neurons, leading to a shift in excitatory/inhibitory balance. CDH13 is also moderating migration of serotonergic neurons in the dorsal raphe nucleus, establishing projections preferentially to the thalamus and cerebellum during brain development. Furthermore, CDH13 is upregulated by chronic stress as well as in depression, suggesting a role in early-life adaptation to stressful experience. Here, we therefore investigated the interaction between Cdh13 variation and neonatal maternal separation (MS) in mice. Met
Ключевые слова:
ADHD; Adhesion; Autism; Cadherin-13 (CDH13); Depression; Early-life stress; Endoplasmic reticulum stress; Mouse; Neurodevelopment; Psychiatric disorders; RNA sequencing; T-cadherin
animal experiment; animal model; animal tissue; Article; CDH13 gene; cell interaction; cell migration; cerebellum; chronic stress; conditioning; controlled study; depression; developmental delay; dorsal raphe nucleus; early life stress; female; GABAergic transmission; gene; gene expression; gene function; gene identification; genetic variation; high risk behavior; hippocampal CA1 region; impulsiveness; learning; locomotion; male; maternal deprivation; memory; motor activity; mouse; nerve cell plasticity; nonhuman; nuclear reprogramming; serotoninergic nerve cell; sex difference; thalamus; upregulation; animal; anxiety; brain; C57BL mouse; deficiency; exploratory behavior; fear; genetics; growth, development and aging; habituation; knockout mouse; mental stress; metabolism; nerve cell; physiology; psychological resilience; psychology; randomization; reinforcement; cadherin; H-cadherin; transcriptome; Animals; Anxiety; Brain; Cadherins; Exploratory Behavior; Extinction, Psychological; Fe
Язык текста: Английский
ISSN: 1878-4216
Kiser D. P.
Popp S.
Schmitt-Böhrer A. G.
Strekalova T. V. Tat`yana Valeryevna 1969-
van d. H. D. L. den Hove D.L.
Lesh K. Yu. Klaus-Peter Yulius 1957-
Rivero O.
Кисер Д. П.
Попп С.
Счмитт-Бöхрер А. Г.
Стрекалова Т. В. Татьяна Валерьевна 1969-
ван д. Х. Д. Л. ден Хове Д.Л.
Леш К. Ю. Клаус-Петер Юлиус 1957-
Риверо О.
Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice
Текст визуальный непосредственный
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Elsevier Science Publisher B.V.
Vol.89 P. 158-168
2019
Статья
ADHD Adhesion Autism Cadherin-13 (CDH13) Depression Early-life stress Endoplasmic reticulum stress Mouse Neurodevelopment Psychiatric disorders RNA sequencing T-cadherin
animal experiment animal model animal tissue Article CDH13 gene cell interaction cell migration cerebellum chronic stress conditioning controlled study depression developmental delay dorsal raphe nucleus early life stress female GABAergic transmission gene gene expression gene function gene identification genetic variation high risk behavior hippocampal CA1 region impulsiveness learning locomotion male maternal deprivation memory motor activity mouse nerve cell plasticity nonhuman nuclear reprogramming serotoninergic nerve cell sex difference thalamus upregulation animal anxiety brain C57BL mouse deficiency exploratory behavior fear genetics growth, development and aging habituation knockout mouse mental stress metabolism nerve cell physiology psychological resilience psychology randomization reinforcement cadherin H-cadherin transcriptome Animals Anxiety Brain Cadherins Exploratory Behavior Extinction, Psychological Fe
Objective: Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the presynaptic compartment of inhibitory GABAergic synapses in the hippocampus and Cdh13 knockout mice show an increased inhibitory drive onto hippocampal CA1 pyramidal neurons, leading to a shift in excitatory/inhibitory balance. CDH13 is also moderating migration of serotonergic neurons in the dorsal raphe nucleus, establishing projections preferentially to the thalamus and cerebellum during brain development. Furthermore, CDH13 is upregulated by chronic stress as well as in depression, suggesting a role in early-life adaptation to stressful experience. Here, we therefore investigated the interaction between Cdh13 variation and neonatal maternal separation (MS) in mice. Met