Аннотация:
Summary. The aim of this study was to estimate a prognostic value of nitric oxide metabolites (NOM) in exhaled breath condensate (EBC) as a marker of asthma control level. We examined 243 patients (of them, 162 males) aged 5 to 17 yrs with atopic asthma. Some of the patients were treated with corticosteroids (CS), others had not been never treated with CS (steroid-naive patients). Asthma control was assessed using the ACQ-5 questionnaire, the EBC NOM total concentration was measured with the Griess-Ilosvay's method modified by S.Soodaeva. In patients with good asthma control, EBC NOM concentration was 6.41 Ѓ} 2.33 μmol / L compared to 8.40 Ѓ} 2.59 μmol / L in patients with partial control and 8.47 Ѓ} 2.77 μmol / L in patients with poor control (р < 0.00001 for both). The EBC NOM concentration from the steroid-naive patients was significantly higher than that from the patients treated with CS. A correlation was found between ACQ-5 score and the total EBC NOM concentration in the whole cohort of patients (r = 0.30, p < 0.00001), in steroid-naive patients (r = 0.42, p < 0.00001), and in patients treated with CS (r = 0.43; p < 0.00001). Discriminant analysis was performed in patients with well controlled asthma and in a combined group of patients with partial and poor asthma control to estimate a prognostic value of EBC NOM and FEV1 as markers of asthma control level. The EBC NOM total concentration predicted asthma control in 63 [%] of the whole cohort, 75 [%] of the steroid-naive patients and in 70 [%] of the patients treated with CS. FEV1 predicted asthma control in 77.3 [%], 75[%] and 74.75[%] of patients, respectively. Combination of EBC NOM total concentration and FEV1 predicted asthma control in 78.92 [%], 79.44 [%] and 82.83 [%] of patients, respectively. Therefore, combination of EBC NOM total concentration and FEV1 is predictive for asthma control in 80 [%] of children with atopic asthma.
[1]«Институт федеральной службы безопасности Российской Федерации, г. Нижний Новгород)»
[2]«Первый медицинский университет им. И.М.Сеченова» Минздрава России
[3]«НИИ пульмонологии» ФМБА России; Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Елисеева Т.И. «Институт федеральной службы безопасности Российской Федерации, г. Нижний Новгород)»
Геппе Н.А. «Первый медицинский университет им. И.М.Сеченова» Минздрава России
Соодаева С.К. «НИИ пульмонологии» ФМБА России; Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
«Институт федеральной службы безопасности Российской Федерации, г. Нижний Новгород)»
«Первый медицинский университет им. И.М.Сеченова» Минздрава России
«НИИ пульмонологии» ФМБА России
Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Eliseeva T.I. «Институт федеральной службы безопасности Российской Федерации, г. Нижний Новгород)»
Geppe N.A. «Первый медицинский университет им. И.М.Сеченова» Минздрава России
Soodaeva S.K. «НИИ пульмонологии» ФМБА России; Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Combined assessment of childhood asthma control level using nitric oxide metabolites in exhaled breath condensate and lung function parameters
Комплексная оценка уровня контроля над бронхиальной астмой у детей на основе определения содержания метаболитов оксида азота в конденсате выдыхаемого воздуха и спирографических параметров
Текст визуальный электронный
Пульмонология
№ 6 С. 51-56
2013
бронхиальная астма
atopic asthma
дети
children
конденсат выдыхаемого воздуха
exhaled breath condensate
метаболизм оксида азота
nitric oxide metabolites
спирография
asthma control
оценка уровня контроля над БА
spirometry
Статья
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Summary. The aim of this study was to estimate a prognostic value of nitric oxide metabolites (NOM) in exhaled breath condensate (EBC) as a marker of asthma control level. We examined 243 patients (of them, 162 males) aged 5 to 17 yrs with atopic asthma. Some of the patients were treated with corticosteroids (CS), others had not been never treated with CS (steroid-naive patients). Asthma control was assessed using the ACQ-5 questionnaire, the EBC NOM total concentration was measured with the Griess-Ilosvay's method modified by S.Soodaeva. In patients with good asthma control, EBC NOM concentration was 6.41 Ѓ} 2.33 μmol / L compared to 8.40 Ѓ} 2.59 μmol / L in patients with partial control and 8.47 Ѓ} 2.77 μmol / L in patients with poor control (р < 0.00001 for both). The EBC NOM concentration from the steroid-naive patients was significantly higher than that from the patients treated with CS. A correlation was found between ACQ-5 score and the total EBC NOM concentration in the whole cohort of patients (r = 0.30, p < 0.00001), in steroid-naive patients (r = 0.42, p < 0.00001), and in patients treated with CS (r = 0.43; p < 0.00001). Discriminant analysis was performed in patients with well controlled asthma and in a combined group of patients with partial and poor asthma control to estimate a prognostic value of EBC NOM and FEV1 as markers of asthma control level. The EBC NOM total concentration predicted asthma control in 63 [%] of the whole cohort, 75 [%] of the steroid-naive patients and in 70 [%] of the patients treated with CS. FEV1 predicted asthma control in 77.3 [%], 75[%] and 74.75[%] of patients, respectively. Combination of EBC NOM total concentration and FEV1 predicted asthma control in 78.92 [%], 79.44 [%] and 82.83 [%] of patients, respectively. Therefore, combination of EBC NOM total concentration and FEV1 is predictive for asthma control in 80 [%] of children with atopic asthma.