Glybochko P.V.
Olefir Y.V. Yu V
Alyaev Y.G. Yu G
Butnaru D.V.
Bezrukov E.A.
Chaplenko A.A.
Zharikova T.M.
I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia, Director of Research Institute for Uronephrology and Human Reproductive Health, Moscow, Russia.
Scientific Center on Expertise of Medical Application Products of Minzdrav of Russia, Moscow, Russia.
Using of cell biocomposite material in tissue engineering of the urinary bladder
Текст визуальный электронный
Urologiia (Moscow, Russia : 1999)
№ 2 С. 116-121
2017
biomedical cell products
cell technologies
organ reconstruction
tissue engineering
urinary bladder
Статья
Обзор
Animals B01.050
Животные B01.050
Cell Line A11.251.210
Клеточные линии A11.251.210
Dogs B01.050.150.900.649.313.750.250.216.200
Собаки B01.050.150.900.649.313.750.250.216.200
Fibroblasts cytology A11.329.228
Фибробласты цитология A11.329.228
Humans B01.050.150.900.649.313.988.400.112.400.400
Человек B01.050.150.900.649.313.988.400.112.400.400
Mesenchymal Stem Cells cytology A11.329.830.500 A11.872.590.500
Мезенхимные стволовые клетки цитология A11.329.830.500 A11.872.590.500
Models, Animal E05.598
Модели на животных E05.598
Rats B01.050.150.900.649.313.992.635.505.700
Крысы B01.050.150.900.649.313.992.635.505.700
Plastic Surgery Procedures E04.617
Методы пластической хирургии E04.617
Tissue Engineering methods E05.481.500.311.500 J01.293.069.249.500
Тканевая инженерия методы E05.481.500.311.500 J01.293.069.249.500
Urinary Bladder surgery A05.810.890
Мочевой пузырь хирургия A05.810.890
Urologic Surgical Procedures E04.950.774
Урологические хирургические операции E04.950.774
Urothelium cytology A10.272.850
Эпителий мочевой системы цитология A10.272.850
Journal Article V02.600
Журнальная статья V02.600
Review V02.600.500 V02.912
Обзор V02.600.500 V02.912
Systematic Review V03.850
Систематический обзор V03.850
In a systematic review, to present an overview of the current situation in the field of tissue engineering of urinary bladder related to the use of cell lines pre-cultured on matrices. The selection of eligible publications was conducted according to the method described in the article Glybochko P.V. et al. "Tissue engineering of urinary bladder using acellular matrix." At the final stage, studies investigating the application of matrices with human and animal cell lines were analyzed. Contemporary approaches to using cell-based tissue engineering of the bladder were analyzed, including the formation of 3D structures from several types of cells, cell layers and genetic modification of injected cells. The most commonly used cell lines are urothelial cells, mesenchymal stem cells and fibroblasts. The safety and efficacy of any types of composite cell structures used in the cell-based bladder tissue engineering has not been proven sufficiently to warrant clinical studies of their usefulness. The results of cystoplasty of rat bladder are almost impossible to extrapolate to humans; besides, it is difficult to predict possible side effects. For the transition to clinical trials, additional studies on relevant animal models are needed.