Аннотация:
The clinical signs of varicocele typically emerge during the puberty. Varicocele is found in 15[%] of men in the general population and 25-35[%] and 50-80[%] of males presenting with primary and secondary infertility, respectively. Factors contributing to the development and recurrence of varicocele include the abnormalities of the testicular venous drainage and outflow (varicose veins are more common on the left than on the right), the anatomical features of the veins of the testicular and prostatic venous plexus, the patients constitution, predisposition to constipation or diarrhea, physical activity. At present, the genetic defects, including the undifferentiated connective tissue dysplasia (UCTD) with hereditary insufficiency of venous valves and the weakness of the testicular vein walls, are thought to play a key role in the formation of a varicocele. Considering the importance of varicocele in the development of male infertility, the role of the UCTD in varicocele formation warrants a detailed investigation to provide an individual approach to patients and predict the disease recurrence.
Studennikova V.V.
Severgina L.O.
Tsarichenko D.G.
Ismailov M.T.
Korovin I.A.
Rapoport L.M.
Zakharov A.I.
Petrukhina Y.V. Yu V
I.M. Sechenov First MSMU, Moscow, Russia.
N.F. Filatov Childrens Hospital 13, Moscow, Russia.
N.I. Pirogov RNRMU, Moscow, Russia.
Current view on the pathogenesis of varicocele and the problem of its recurrence
Текст визуальный электронный
Urologiia (Moscow, Russia : 1999)
№ 1 С. 150-154
2018
mechanisms of varicocele development
molecular genetic factors
recurrent varicocele
undifferentiated connective tissue dysplasia
Статья
Age Factors N05.715.350.075 N06.850.490.250
Возрастные факторы N05.715.350.075 N06.850.490.250
Humans B01.050.150.900.649.313.988.400.112.400.400
Человек B01.050.150.900.649.313.988.400.112.400.400
Male
Мужской
Recurrence C23.550.291.937
Рецидив C23.550.291.937
Undifferentiated Connective Tissue Diseases complications C17.300.849 C20.111.904
Undifferentiated Connective Tissue Diseases genetics C17.300.849 C20.111.904
Соединительной ткани болезни недифференцированные осложнения C17.300.849 C20.111.904
Соединительной ткани болезни недифференцированные генетика C17.300.849 C20.111.904
Varicocele epidemiology C12.100.500.936 C12.200.294.936 C14.907.903
Varicocele etiology C12.100.500.936 C12.200.294.936 C14.907.903
Varicocele genetics C12.100.500.936 C12.200.294.936 C14.907.903
Варикоцеле эпидемиология C12.100.500.936 C12.200.294.936 C14.907.903
Варикоцеле этиология C12.100.500.936 C12.200.294.936 C14.907.903
Варикоцеле генетика C12.100.500.936 C12.200.294.936 C14.907.903
Journal Article V02.600
Журнальная статья V02.600
The clinical signs of varicocele typically emerge during the puberty. Varicocele is found in 15[%] of men in the general population and 25-35[%] and 50-80[%] of males presenting with primary and secondary infertility, respectively. Factors contributing to the development and recurrence of varicocele include the abnormalities of the testicular venous drainage and outflow (varicose veins are more common on the left than on the right), the anatomical features of the veins of the testicular and prostatic venous plexus, the patients constitution, predisposition to constipation or diarrhea, physical activity. At present, the genetic defects, including the undifferentiated connective tissue dysplasia (UCTD) with hereditary insufficiency of venous valves and the weakness of the testicular vein walls, are thought to play a key role in the formation of a varicocele. Considering the importance of varicocele in the development of male infertility, the role of the UCTD in varicocele formation warrants a detailed investigation to provide an individual approach to patients and predict the disease recurrence.