Аннотация:
Urolithiasis is a widespread chronic disease; its prevalence has been steadily increasing over the past 50 years. Urolithiasis accounts for a large proportion urologic diseases, exceeded only by urinary tract infections and diseases of the prostate. Urate urolithiasis refers to a type of urolithiasis, characterized by the formation of kidney stones consisting of uric acid or its salts. In populations of industrialized countries, uric acid is the second or third most frequently occurring stone-forming substance. The article summarizes the data on the global prevalence of both urolithiasis as a whole and urate urolithiasis in particular. The authors provide a detailed overview of the formation of the current concept of the urate urolithiasis pathogenesis and the management of the disease. The main focus is placed on the possibilities and the role of litholytic (stone-dissolving) therapy for urate urolithiasis and the mechanisms of the action of citrate preparations.
Frolova E.A.
Tsarichenko D.G.
Saenko V.S.
Rapoport L.M.
Research Institute for Uronephrology and Human Reproductive Health, I.M. Sechenov First MSMU of Minzdrav of Russia MSU Moscow, Russia.
Urate urolithiasis: pathogenesis and possibilities of conservative therapy
Текст визуальный электронный
Urologiia (Moscow, Russia : 1999)
№ 5 С. 146-152
2018
Keyword: urate urolithiasis
citrate therapy
conservative therapy
litholysis
Статья
Обзор
Conservative Treatment E02.197
Консервативное лечение E02.197
Humans B01.050.150.900.649.313.988.400.112.400.400
Человек B01.050.150.900.649.313.988.400.112.400.400
Uric Acid D03.132.960.877 D03.633.100.759.758.824.877
Мочевая кислота D03.132.960.877 D03.633.100.759.758.824.877
Urinary Calculi C12.050.351.968.967.500 C12.200.777.967.500 C12.950.967.500 C23.300.175.850
Мочевой камень C12.050.351.968.967.500 C12.200.777.967.500 C12.950.967.500 C23.300.175.850
Urolithiasis C12.050.351.968.967 C12.200.777.967 C12.950.967
Уролитиаз C12.050.351.968.967 C12.200.777.967 C12.950.967
Journal Article V02.600
Журнальная статья V02.600
Review V02.600.500 V02.912
Обзор V02.600.500 V02.912
Urolithiasis is a widespread chronic disease; its prevalence has been steadily increasing over the past 50 years. Urolithiasis accounts for a large proportion urologic diseases, exceeded only by urinary tract infections and diseases of the prostate. Urate urolithiasis refers to a type of urolithiasis, characterized by the formation of kidney stones consisting of uric acid or its salts. In populations of industrialized countries, uric acid is the second or third most frequently occurring stone-forming substance. The article summarizes the data on the global prevalence of both urolithiasis as a whole and urate urolithiasis in particular. The authors provide a detailed overview of the formation of the current concept of the urate urolithiasis pathogenesis and the management of the disease. The main focus is placed on the possibilities and the role of litholytic (stone-dissolving) therapy for urate urolithiasis and the mechanisms of the action of citrate preparations.