Аннотация:
New information about typical changes in the immune status at both local and systemic level in various forms of acute pyelonephritis is provided in the second part of the review. The literature review and analysis of current national and foreign literature dedicated to immune disorders in various forms of acute pyelonephritis has been performed. The degree and nature of changes in systemic and local immunological parameters in nonobstructive and obstructive, serous and purulent forms are highlighted in details. In particular, it has been established that in patients with obstructive and purulent pyelonephritis, there are more pronounced changes in the serum and urine level of cytokines and complement factors in comparison with serous and non-obstructive pyelonephritis. Recommendations are given on monitoring of the immunological status in patients with various forms of acute pyelonephritis in order to optimize treatment approaches. In addition, the rationales for effective pathogenetic, including specific, immunotherapy drugs for various forms of pyelonephritis are presented.
Shatokhin M.N.
Konoply A.I.
Kholimenko I.M.
Besprozvanniy V.I.
Mavrin M.Y. M Yu
Russian Medical Academy of Continuous Further Professional Education of the Ministry of Healthcare of the Russian Federation, Urological Center of the Scientific Clinical Center of Russian Railways, Moscow, Russia.
Kursk State Medical University, Kursk, Russia.
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia.
Immune system disorders in acute pyelonephritis. II art
Текст визуальный электронный
Urologiia (Moscow, Russia : 1999)
№ 1 С. 110-114
2020
acute pyelonephritis
immune system disorders
review
Статья
Обзор
Acute Disease C23.550.291.125
Острая болезнь C23.550.291.125
Cytokines D12.644.276.374 D12.776.467.374 D23.529.374
Цитокины D12.644.276.374 D12.776.467.374 D23.529.374
Humans B01.050.150.900.649.313.988.400.112.400.400
Человек B01.050.150.900.649.313.988.400.112.400.400
Immune System Diseases C20
Иммунной системы расстройства C20
Pyelonephritis C12.050.351.968.419.570.643.790 C12.050.351.968.419.570.821.717 C12.200.777.419.570.643.790 C12.200.777.419.570.821.717 C12.950.419.570.643.790 C12.950.419.570.821.717
Пиелонефрит C12.050.351.968.419.570.643.790 C12.050.351.968.419.570.821.717 C12.200.777.419.570.643.790 C12.200.777.419.570.821.717 C12.950.419.570.643.790 C12.950.419.570.821.717
Journal Article V02.600
Журнальная статья V02.600
Review V02.600.500 V02.912
Обзор V02.600.500 V02.912
New information about typical changes in the immune status at both local and systemic level in various forms of acute pyelonephritis is provided in the second part of the review. The literature review and analysis of current national and foreign literature dedicated to immune disorders in various forms of acute pyelonephritis has been performed. The degree and nature of changes in systemic and local immunological parameters in nonobstructive and obstructive, serous and purulent forms are highlighted in details. In particular, it has been established that in patients with obstructive and purulent pyelonephritis, there are more pronounced changes in the serum and urine level of cytokines and complement factors in comparison with serous and non-obstructive pyelonephritis. Recommendations are given on monitoring of the immunological status in patients with various forms of acute pyelonephritis in order to optimize treatment approaches. In addition, the rationales for effective pathogenetic, including specific, immunotherapy drugs for various forms of pyelonephritis are presented.